NCT05291637 (PLATO) is a clinical trial in Stroke, Acute Ischemic, sponsored by Boston Medical Center.

Who is sponsoring NCT05291637?

NCT05291637 is sponsored by Boston Medical Center.

What condition does NCT05291637 study?

NCT05291637 studies Stroke, Acute Ischemic.

Is NCT05291637 still recruiting?

NCT05291637 is currently completed. Last updated 4 June 2024.

Last reviewed 2024-06-04 · How we verify

NCT05291637: PLATO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Posterior cerebraL ArTery Occlusion Study

Completed Last updated 4 June 2024

What this trial tests

trial in Stroke, Acute Ischemic in 1,282 participants. Completed in 31 January 2023.

Timeline

5 January 2022

Primary endpoint
31 May 2022

31 January 2023

Quick facts

Lead sponsor	Boston Medical Center
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,282
Start date	5 January 2022
Primary completion	31 May 2022
Estimated completion	31 January 2023
Sites	22 locations across Italy, Finland, Germany, Switzerland, Portugal, United States, Spain

Conditions studied

Stroke, Acute Ischemic — all drugs for Stroke, Acute Ischemic →

Sponsor

Boston Medical Center

Who can join

Adults 18 to 89, any sex, with Stroke, Acute Ischemic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

For this retrospective study, the investigators will collect and analyze data of patients who presented with posterior artery occlusion and underwent mechanical thrombectomy (the type of endovascular stroke treatment) and intravenous thrombolysis (the type of non-endovascular stroke treatment). The electronic health records will be queried for the demographic, medical history, and outcomes data of all patients with posterior cerebral artery occlusion who underwent mechanical thrombectomy, intravenous thrombolysis (IVT), or medical management.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site.
Strambo D, Michel P, Nguyen TN, Abdalkader M, et al · · 2024 · cited 26× · PMID 38753954 · DOI 10.1161/strokeaha.124.047383
First-Line Stent Retriever Versus Contact Aspiration or Combined Technique for Endovascular Therapy of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study.
Nguyen TN, Abdalkader M, Qureshi MM, Michel P, et al · · 2024 · cited 3× · PMID 41586053 · DOI 10.1161/svin.123.001004
Is Thrombectomy Worth It for Isolated Posterior Cerebral Artery Occlusion? Meta-Analysis and Trial Sequential Analysis.
Jhou HJ, Lee CH, Tsai YC, Chen PH, et al · · 2024 · PMID 41583603 · DOI 10.1161/svin.123.001084
Abstract 012: First‐line Stent Retriever Versus Contact Aspiration or Combined Technique for Posterior Cerebral Artery Occlusion EVT
Klein P, Nguyen T, Abdalkader M, Qureshi M, et al · · 2023

Verify or expand the search:

Other recruiting trials for Stroke, Acute Ischemic

Currently open trials in the same condition.

NCT06987305 — Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window · Phase 3 · recruiting
NCT06768138 — Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke · Phase 3 · recruiting
NCT06388148 — Endovascular Treatment for eXtra-Large Ischemic Stroke · NA · recruiting
NCT06374667 — The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Larg · NA · recruiting
NCT06010641 — Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES · NA · recruiting

Other Boston Medical Center trials

Trials by the same sponsor.

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NCT06489522 — Parenting Intervention for Mothers With Substance Use Disorder · NA · completed
NCT05769218 — PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study · NA · recruiting
NCT06427967 — A Novel Social Emotional Learning Curriculum for Youth With Epilepsy · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05291637 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Boston Medical Center
Last refreshed: 4 June 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05291637.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing