NCT05286658

Behavioral and Neural Responses to External Alterations of Speech Variability

Completed NA Results posted Last updated 13 February 2024

What this trial tests

NA trial testing MEG/EEG in Speech in 17 participants. Completed in 19 July 2022.

Timeline

19 October 2021

Primary endpoint
19 July 2022

19 July 2022

Quick facts

Lead sponsor	University of Wisconsin, Madison
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	17
Start date	19 October 2021
Primary completion	19 July 2022
Estimated completion	19 July 2022
Sites	2 locations across United States

Drugs / interventions tested

• MEG/EEG
• MRI — full drug profile →
• Speaking Tasks

Conditions studied

• Speech — all drugs for Speech →

Sponsor

University of Wisconsin, Madison

Who can join

18 and older, any sex, with Speech. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Speaking-Induced Suppression (SIS) Change, Defined as the Percent Change of SIS (the Z-score Difference in Average M100 Amplitude in the Speak Condition Compared With the Listen Condition) From Baseline to Test Phases Primary · Data were collected over 3 individual hour-long MEG sessions over 3 weeks (pre-test vs. post-test compared within the same session).

The dependent measure is the speaking-induced suppression (SIS) defined as the z-score difference in average M100 amplitude in the speak condition compared with the listen condition. The M100 peak is defined as the peak activity between 75 and 150 ms after stimulus onset; peaks will be confirmed by visual inspection. The percent change in this SIS from the pre-test (baseline phase at the beginning of the MEG scan) to the post-test (test phase at the end of the MEG scan) is evaluated for each of three visits: "in", "out", and "control".

"In": inward variability condition

Group	Value	95% CI
Healthy Adult Speakers	7.4	± 16.1

"Out": outward variability condition

Group	Value	95% CI
Healthy Adult Speakers	-22.2	± 8.2

"Control": control condition

Group	Value	95% CI
Healthy Adult Speakers	28.9	± 15.6

Sponsor's own description

The purpose of this research study is to understand how the brain processes and controls speech in healthy people. The investigators are doing this research because it will help identify the mechanisms that allow people to perceive their own speech errors and to learn new speech sounds, which may be applied to people who have communication disorders. 15 participants will be enrolled into this part of the study and can expect to be on study for 3-4 visits of 2-4 hours each.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.