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NCT05285189
Effects of Isotonic Saline As Irrigation Fluid In Transurethral Resection of Prostate (TUR-P) Operations
trial in Hyperchloremic Acidosis in 75 participants. Status unknown.
29 July 2022
Quick facts
| Lead sponsor | Istanbul University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 75 |
| Start date | 1 January 2019 |
| Primary completion | 29 July 2022 |
| Estimated completion | 31 July 2022 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Hyperchloremic Acidosis — all drugs for Hyperchloremic Acidosis →
- Transurethral Resection of Prostate — all drugs for Transurethral Resection of Prostate →
- Normal Anion Gap Metabolic Acidosis — all drugs for Normal Anion Gap Metabolic Acidosis →
- Anesthesia — all drugs for Anesthesia →
Sponsor
Istanbul University
Who can join
18 and older, male only, with Hyperchloremic Acidosis or Transurethral Resection of Prostate. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Benign hypertrophy of the prostate (BPH) is a disease seen in 20% of men over the age of 50 and in 40% of those over the age of 70. The gold standard in the treatment of BPH is transurethral resection of the prostate using high-frequency diathermy. Today, this process is done with the bipolar technique, in which isotonic saline (isotonic sodium chloride %0.9) is used as the irrigation fluid. This irrigation fluid, which is used after long operation and deep tissue resection, can enter the systemic circulation through the opened venous sinuses. It has been shown in clinical studies that postoperative acute hyperchloremia (serum Cl level \> 110 mmol/L) develops after the use of intravenous normal saline solution in large amounts in the perioperative period. Our aim is to detect hyperchloremia and associated metabolic acidosis without anion gap in the follow-up of these patients. Our primary hypothesis in this study is that hyperchloremic metabolic acidosis will develop due to the high amount of normal saline used in TUR-P. .
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05285189 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istanbul University
- Last refreshed: 31 March 2022
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