NCT05284149: HSN

Study the Impact of Hirsutella Sinensis Nutrient Supplements Has on Improving Muscle Health and Metabolism in Elderly

Status unknown NA Last updated 17 March 2022

What this trial tests

NA trial testing Hirsutella Sinensis Nutrient Supplements in Sarcopenia in 100 participants. Status unknown.

Timeline

15 February 2022

Primary endpoint
15 February 2024

15 February 2024

Quick facts

Lead sponsor	Chang Gung Memorial Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	100
Start date	15 February 2022
Primary completion	15 February 2024
Estimated completion	15 February 2024
Sites	1 location across Taiwan

Drugs / interventions tested

• Hirsutella Sinensis Nutrient Supplements
• Placebo

Conditions studied

• Sarcopenia — all drugs for Sarcopenia →
• Old Age; Debility — all drugs for Old Age; Debility →
• Muscle Loss — all drugs for Muscle Loss →

Sponsor

Chang Gung Memorial Hospital

Who can join

50 and older, any sex, with Sarcopenia or Old Age; Debility. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Sarcopenia has now been officially recognized as a muscle disease related to aging, which may increase the risk of falls and fractures and both heart and respiratory diseases in the elderly. Sarcopenia causes inconvenience in the elderly, affecting their quality of life and often requiring long-term care or even resulting in death. Moreover, the elderly often encountered malnutrition due to inadequate nutrient intake and scarce nutrient diversity. Furthermore, malnutrition is often one of the leading causes of sarcopenia. Therefore, effective nutritional supplementation is essential to improve or prevent muscle loss for the elderly.

Cordyceps sinensis is a well-known valuable traditional Chinese medicine and Hirsutella sinensis was an asexual strain of Cordyceps sinensis. Researchers have found that Hirsutella sinensis can help to increase connection between gastrocnemius muscle fibers and spinal nerve under the amyotrophic lateral sclerosis animal disease model. However, culturing conditions for Hirsutella sinensis are extremely difficult and long, one of the key culturing condition is the temperature, must be maintaining at 16-20℃for 45 days. Fortunately, Grape King Biotech has core technology using liquid fermentation which greatly shortened the cultivation time, thus, providing sufficient and safe products to patients.

The investigators designed a randomized placebo-controlled study first to investigate the relationship and clinical impact Hirsutella Sinensis had on muscle mass and function in the elderly. Second, investigate the metabolic impact Hirsutella Sinensis had on muscle mass.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Looking at frailty and intrinsic capacity through a geroscience lens: the ICFSR & Geroscience Task Force.
   de Souto Barreto P, Rolland Y, Ferrucci L, Arai H, et al · · 2023 · cited 21× · PMID 37985720 · DOI 10.1038/s43587-023-00531-w
2. Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?
   Nagpal D, Nema S, Nagpal S, Pandey MM, et al · · 2025 · cited 2× · PMID 41008984 · DOI 10.3390/antiox14091078