Last reviewed · How we verify
NCT05281848
Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35
NA trial testing Non-surgical periodontal treatment in Periodontitis in 55 participants. Completed in 7 March 2022.
1 June 2019
Quick facts
| Lead sponsor | Gazi University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 55 |
| Start date | 1 January 2018 |
| Primary completion | 1 June 2019 |
| Estimated completion | 7 March 2022 |
| Sites | 2 locations across Turkey (Türkiye) |
Drugs / interventions tested
- Non-surgical periodontal treatment
Conditions studied
- Periodontitis — all drugs for Periodontitis →
- Periodontal Diseases — all drugs for Periodontal Diseases →
- Smoking — all drugs for Smoking →
- Smoking, Tobacco — all drugs for Smoking, Tobacco →
Sponsor
Gazi University
Who can join
Adults 18 to 70, any sex, with Periodontitis or Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response. The role of cytokines in the pathogenesis of periodontal disease is clearly indicated in the literature; it has been shown that microorganisms that cause periodontal disease cause cytokine increase in saliva, gingival tissue and gingival crevicular fluid. Among these cytokines, interleukin (IL) -17 is proinflammatory and IL-35 is antiinflammatory and has been associated with periodontal disease.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Non-surgical periodontal treatment effects on IL-17 and IL-35 levels in smokers and non-smokers with periodontitis.
Ezgi Sila T, Gulay T, Aysegul AY, Melek Y. · · 2025 · cited 1× · PMID 40971113 · DOI 10.1007/s10266-025-01207-0
Verify or expand the search:
- PubMed search for NCT05281848
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Non-surgical periodontal treatment
Trials testing the same drug.
- NCT07070453 — Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis · NA · recruiting
- NCT06070181 — Effectiveness of Adjunctive Therapy of Emdogain®FL in Non-surgical Periodontal Treatment · NA · recruiting
- NCT05971706 — Ozone Application in Periodontal Treatment · NA · completed
- NCT06605547 — The Effect of I-PRF As An Adjunct to Non-Surgical Periodontal Therapy on Clinical Parameters in Smokers With Periodontit · NA · completed
- NCT05502601 — Periodontal Therapy in Patients With Rheumatoid Arthritis · NA · unknown
Other recruiting trials for Periodontitis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
- NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
- NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
- NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting
Other Gazi University trials
Trials by the same sponsor.
- NCT07500857 — Gamification in Stoma Care Education for Nursing Students · NA · not yet recruiting
- NCT07471737 — Patient Safety and Medical Errors in Nursing Education: Learning by Doing and Experiencing With Simulated Patients · NA · not yet recruiting
- NCT07440563 — Auricular Vagus Nerve Stimulation Combined With Rehabilitation in Parkinson's Disease · NA · enrolling by invitation
- NCT07496398 — Median and Ulnar Nerve Function in Tattoo Artists · recruiting
- NCT07471386 — Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05281848 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Gazi University
- Last refreshed: 16 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05281848.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing