NCT05281237

Avecure Flexible Microwave Ablation Probe For Lung Nodules

Recruiting now NA Last updated 8 April 2026

What this trial tests

NA trial testing AveCure 16 Gauge Flexible Microwave Ablation Probe in Stage I - II Primary Lung Cancer in 10 participants. Currently enrolling.

Timeline

1 June 2022

Primary endpoint
30 December 2026

30 June 2027

Quick facts

Lead sponsor	Beth Israel Deaconess Medical Center
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	10
Start date	1 June 2022
Primary completion	30 December 2026
Estimated completion	30 June 2027
Sites	1 location across United States

Drugs / interventions tested

• AveCure 16 Gauge Flexible Microwave Ablation Probe

Conditions studied

• Stage I - II Primary Lung Cancer — all drugs for Stage I - II Primary Lung Cancer →
• Stage I Lung Cancer — all drugs for Stage I Lung Cancer →
• Stage II Lung Cancer — all drugs for Stage II Lung Cancer →
• Lung Cancer Stage I — all drugs for Lung Cancer Stage I →

Sponsor

Beth Israel Deaconess Medical Center

Who can join

22 and older, any sex, with Stage I - II Primary Lung Cancer or Stage I Lung Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research study to determine the effectiveness of the AveCure Flexible Microwave Ablation Probe to destroy cancerous lung nodules up to 3 c m in size.

This research study involves microwave ablation (MWA)

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Advanced Imaging for Robotic Bronchoscopy: A Review.
   Ravikumar N, Ho E, Wagh A, Murgu S. · · 2023 · cited 18× · PMID 36900134 · DOI 10.3390/diagnostics13050990
2. Endoscopic Technologies for Peripheral Pulmonary Lesions: From Diagnosis to Therapy.
   Fantin A, Manera M, Patruno V, Sartori G, et al · · 2023 · cited 12× · PMID 36836612 · DOI 10.3390/life13020254
3. Ablation combined with video-assisted thoracic surgery hybrid technique for multiple primary lung cancer.
   Xu R, Zhang G, Che Y, Ren N, et al · · 2025 · cited 3× · PMID 40546939 · DOI 10.1016/j.isci.2025.112703
4. ERJ Advances: interventional bronchoscopy.
   Garner JL, Shah PL, Herth F, Slebos DJ. · · 2024 · cited 3× · PMID 38991719 · DOI 10.1183/13993003.01946-2023
5. Safety and feasibility of bronchoscopic microwave ablation technology for peripheral lung cancer: a multi-center, prospective, single-arm study protocol.
   Beattie J, Parrish R, Ayasa L, Aranguren P, et al · · 2025 · cited 1× · PMID 41137055 · DOI 10.1186/s12893-025-03230-y