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NCT05278000: PACIFI
Improving Adherence to Controller Medication in Children With Asthma
trial testing Presence of scarcity mindset in Asthma in Children in 201 participants. Completed in 18 July 2025.
12 July 2025
Quick facts
| Lead sponsor | St. Justine's Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 201 |
| Start date | 25 August 2022 |
| Primary completion | 12 July 2025 |
| Estimated completion | 18 July 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Presence of scarcity mindset
Conditions studied
- Asthma in Children — all drugs for Asthma in Children →
- Adherence, Medication — all drugs for Adherence, Medication →
Sponsor
St. Justine's Hospital
Who can join
Adults 2 to 17, any sex, with Asthma in Children or Adherence, Medication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Asthma is a common pediatric condition that can be well controlled with regular use of controller medications, however adherence to these is low, resulting in preventable exacerbations and important short- and long-term morbidity. This project's aim is to understand cognitive factors influencing adherence to medication among children with asthma, examining specifically the influence of scarcity (a mindset experienced by those with less than they need, which is cognitively taxing) and future discounting (the focus on present concerns at the expense of distant ones). Using a single-centre, 12-month, prospective observation cohort study of 300 families of children with asthma, the objectives of this study are to: 1. Identify the relationship between scarcity, future discounting, and adherence to asthma medication. 2. Evaluate whether unmet social needs are associated with scarcity and future discounting. 3. Determine whether scarcity and future discounting mediate the relationship between unmet social needs and adherence to medication. Primary outcome will be adherence to controller medication, which will be measured for the 12 months of follow-up on a scale of 0 to 100%, by the 'proportion of prescribed days covered (PPDC)', a validated index calculated as the number of days for which the drug was dispensed by a pharmacy, divided by the number of days for which it was prescribed. Other measures include screening families for unmet social needs, psychometric testing to document scarcity and future discounting. This study will increase our understanding of how cognitive factors influence adherence to asthma controller medication, which will be instrumental in developing targeted interventions to improve adherence, especially for families experiencing with unmet social needs.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of Unmet Social Needs, Scarcity, and Future Discounting on Adherence to Treatment in Children With Asthma: Protocol for a Prospective Cohort Study.
Drouin O, Perez T, Barnett TA, Ducharme FM, et al · · 2023 · cited 3× · PMID 36881458 · DOI 10.2196/37318
Verify or expand the search:
- PubMed search for NCT05278000
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Asthma in Children
Currently open trials in the same condition.
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- NCT07137923 — SMART Implementation-Effectiveness Trial 1 · NA · recruiting
- NCT06851715 — Improving Quality of Life for Teenagers With Asthma · NA · recruiting
Other St. Justine's Hospital trials
Trials by the same sponsor.
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- NCT06192368 — Virtual Reality Program to Reduce Stress in Neonatal Nurses · NA · completed
- NCT06217510 — Pilot Project on the Automatic Design and 3D Printing of Adolescent Idiopathic Scoliosis Braces (Phase 1) · NA · unknown
- NCT06173102 — Cranial Orthosis Therapy for Plagiocephaly: an RCT Pilot Study Comparing Cranial Orthosis to the Natural Course · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05278000 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by St. Justine's Hospital
- Last refreshed: 23 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05278000.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing