Last reviewed · How we verify
NCT05276999
Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET"
NA trial testing Healthcare provider education in Rheumatic Heart Disease in 66,123 participants. Completed in 30 March 2024.
30 March 2024
Quick facts
| Lead sponsor | Children's Hospital Medical Center, Cincinnati |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 66,123 |
| Start date | 31 January 2022 |
| Primary completion | 30 March 2024 |
| Estimated completion | 30 March 2024 |
| Sites | 1 location across Uganda |
Drugs / interventions tested
- Healthcare provider education
- Community Awareness campaign
Conditions studied
- Rheumatic Heart Disease — all drugs for Rheumatic Heart Disease →
Sponsor
Children's Hospital Medical Center, Cincinnati
Who can join
Adults 5 to 15, any sex, with Rheumatic Heart Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary objective of this study is to determine the impact of a pragmatic RHD primary prevention program in Uganda. The secondary Objective are as follow: 1. To improve guideline-based care for sore throat through frontline healthcare provider education on clinical decision rules and guideline-based primary prevention. 2. To increase health seeking behavior for sore throat thorough a multifaceted community awareness campaign.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Implementation and evaluation of a pragmatic community streptococcal treatment programme to improve rheumatic heart disease primary prevention in Uganda.
Ndagire E, Rwebembera J, Kaudha G, Pulle J, et al · · 2026 · PMID 41956705 · DOI 10.1136/bmjgh-2024-018791 -
Community co-design of contextually relevant rheumatic heart disease primary prevention.
Miller M, Vaughn LM, Nakitto M, Pulle J, et al · · 2025 · PMID 41309145 · DOI 10.1136/bmjgh-2025-019733
Verify or expand the search:
- PubMed search for NCT05276999
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Rheumatic Heart Disease
Currently open trials in the same condition.
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- NCT05693545 — GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial · Phase 2 · active not recruiting
- NCT05991219 — Screening and Secondary Prevention Rheumatic Heart Disease Study · recruiting
- NCT05504928 — Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease · NA · recruiting
Other Children's Hospital Medical Center, Cincinnati trials
Trials by the same sponsor.
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- NCT07217444 — Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05276999 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital Medical Center, Cincinnati
- Last refreshed: 4 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05276999.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing