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NCT05268913: READ RISK

Towards Early Detection of Breast Cancer in High Risk Population

Status unknown Last updated 7 March 2022
What this trial tests

trial testing MRI scan in Breast Cancer in 120 participants. Status unknown.

Timeline
1 March 2022
Primary endpoint
1 May 2024
1 May 2024

Quick facts

Lead sponsorUniversity of Aberdeen
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment120
Start date1 March 2022
Primary completion1 May 2024
Estimated completion1 May 2024
Sites1 location across United Kingdom

Drugs / interventions tested

Conditions studied

Sponsor

University of Aberdeen

Who can join

Adults 18 to 55, female only, with Breast Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Breast cancer is a major and growing health challenge, and the leading cause of cancer in women. As population obesity rates increase, the number of new breast cancer diagnosis continues to rise. Despite treatment advances, breast cancer remains an important cause of premature mortality, taking women in the prime of life. Although underlying susceptibility caused by mutation in the genes including BRCA1/2 is increasingly identified, current pre-symptomatic screening for the general population and those at high genetic risk remains sub-optimal, with high false negative and positive rates. Alteration of breast lipid composition has been observed by us and others in patients with breast cancer and is thought to precede onset. We have developed and tested a novel method to allow a standard 3T MRI scanner to perform quantitative 3D mapping of specific lipid molecules in the breast. We will investigate if this method can detect very early breast cancers, and compare the amount and spread of lipid composition in breast tissue of premenopausal women with very high genetic risk of breast cancer, women with breast cancer and women with obesity.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors.
    Fodil M, Blanckaert V, Ulmann L, Mimouni V, et al · · 2022 · cited 13× · PMID 35805595 · DOI 10.3390/ijerph19137936

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Other trials of MRI scan

Trials testing the same drug.

Other recruiting trials for Breast Cancer

Currently open trials in the same condition.

Other University of Aberdeen trials

Trials by the same sponsor.

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