Last reviewed · How we verify
NCT05266066: VATICAN
Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation
NA trial testing Clinical observation without antibiotic therapy for VAT in Ventilator Associated Tracheobronchitis in 590 participants. Currently enrolling.
1 November 2026
Quick facts
| Lead sponsor | Hospital Sirio-Libanes |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 590 |
| Start date | 11 July 2022 |
| Primary completion | 1 November 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 16 locations across Brazil |
Drugs / interventions tested
- Clinical observation without antibiotic therapy for VAT
- 7 day antibiotic course for VAT
Conditions studied
- Ventilator Associated Tracheobronchitis — all drugs for Ventilator Associated Tracheobronchitis →
- Tracheobronchitis — all drugs for Tracheobronchitis →
Sponsor
Hospital Sirio-Libanes
Who can join
18 and older, any sex, with Ventilator Associated Tracheobronchitis or Tracheobronchitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The Ventilator Associated tracheobronchitis Initiative to Conduct Antibiotic evaluation (VATICAN) trial is a national, multicenter, non-inferiority trial in ICU patients comparing antibiotic treatment for 7 days versus clinical observation without antibiotic treatment for patients with ventilator-associated tracheobronchitis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation): protocol for a multicenter randomized open-label trial of watchful waiting versus antimicrobial therapy for ventilator-associated tracheobronchitis.
IMPACTO-MR, VATICAN Trial Investigators and BRICNet, Tomazini BM, Besen BAMP, et al · · 2024 · cited 1× · PMID 39194024 · DOI 10.62675/2965-2774.20240029-en
Verify or expand the search:
- PubMed search for NCT05266066
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05266066 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Sirio-Libanes
- Last refreshed: 19 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05266066.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing