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NCT05265793

Camrelizumab Combined With Apatinib in the Treatment of Advanced Sarcomatoid Carcinoma or Carcinosarcoma

Status unknown Phase 2 Last updated 4 March 2022
What this trial tests

Phase 2 trial testing Camrelizumab Combined With Apatinib in PD-1 Immunotherapy in 45 participants. Status unknown.

Timeline
21 November 2021
Primary endpoint
30 March 2023
30 June 2023

Quick facts

Lead sponsorFudan University
PhasePhase 2
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment45
Start date21 November 2021
Primary completion30 March 2023
Estimated completion30 June 2023
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

Fudan University

Who can join

Adults 18 to 75, any sex, with PD-1 Immunotherapy or VEGFR-TKI. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is to explore the treatment of advanced sarcomatoid carcinoma or Carcinosarcoma with Carrelizumab combined with Apatinib, in order to provide guidance and experience for new combined therapy in clinic.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Frontiers of Ovarian Carcinosarcoma.
    Ismail A, Choi S, Boussios S. · · 2023 · cited 18× · PMID 37938504 · DOI 10.1007/s11864-023-01138-4
  2. Molecular Characterizations of Gynecologic Carcinosarcomas: A Focus on the Immune Microenvironment.
    Nakad Borrego S, Lengyel E, Kurnit KC. · · 2022 · cited 6× · PMID 36139624 · DOI 10.3390/cancers14184465
  3. Sintilimab combined with anlotinib as first-line treatment for advanced sarcomatoid carcinoma of head and neck: a case report and literature review.
    Wang L, Huang Y, Sun X. · · 2024 · cited 1× · PMID 38725630 · DOI 10.3389/fonc.2024.1362160
  4. Metastatic Sarcomatoid Carcinoma of the Larynx: A Case Report.
    Derfoufi J, Rezzoug F, Al Jarroudi O, Brahmi SA, et al · · 2024 · PMID 39463652 · DOI 10.7759/cureus.70331

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