NCT05259410

Time Restricted Eating During Chemotherapy for Breast Cancer

Recruiting now NA Last updated 1 October 2025

What this trial tests

NA trial testing TRE in Breast Cancer Female in 40 participants. Currently enrolling.

Timeline

1 August 2022

Primary endpoint
1 March 2026

1 March 2026

Quick facts

Lead sponsor	University of Illinois at Chicago
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	40
Start date	1 August 2022
Primary completion	1 March 2026
Estimated completion	1 March 2026
Sites	1 location across United States

Drugs / interventions tested

• TRE
• MedTRE

Conditions studied

• Breast Cancer Female — all drugs for Breast Cancer Female →

Sponsor

University of Illinois at Chicago

Who can join

Adults 25 to 99, female only, with Breast Cancer Female. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Breast cancer is the most common cancer in the United States however, little is known about how diet can affect cancer treatment. Pre-clinical murine studies report intermittent fasting increases effectiveness of chemotherapy and decreases treatment related adverse events. The proposed research will demonstrate that time restricted eating, a form of intermittent fasting, will improve treatment related outcomes, patient related outcomes, and limit treatment related weight gain and fat mass accretion.Time restricted eating combined with a mediterranean diet will also be feasible and improve cardiometabolic risk more than TRE alone or standard care.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential.
   Xiao YL, Gong Y, Qi YJ, Shao ZM, et al · · 2024 · cited 120× · PMID 38462638 · DOI 10.1038/s41392-024-01771-x
2. Time-restricted eating: Watching the clock to treat obesity.
   Ezpeleta M, Cienfuegos S, Lin S, Pavlou V, et al · · 2024 · cited 83× · PMID 38176412 · DOI 10.1016/j.cmet.2023.12.004
3. Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review.
   Mercier BD, Tizpa E, Philip EJ, Feng Q, et al · · 2022 · cited 28× · PMID 36291933 · DOI 10.3390/cancers14205149
4. Obesity, cancer risk, and time-restricted eating.
   Das M, Webster NJG. · · 2022 · cited 25× · PMID 35984550 · DOI 10.1007/s10555-022-10061-3
5. Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment.
   Khalifa A, Guijarro A, Nencioni A. · · 2024 · cited 17× · PMID 39064705 · DOI 10.3390/nu16142262
6. Molecular crosstalk between circadian clock and cancer and therapeutic implications.
   Qu M. · · 2023 · cited 13× · PMID 36937362 · DOI 10.3389/fnut.2023.1143001
7. The Clinical Impact of Time-restricted Eating on Cancer: A Systematic Review.
   Stringer EJ, Cloke RWG, Van der Meer L, Murphy RA, et al · · 2025 · cited 5× · PMID 39212676 · DOI 10.1093/nutrit/nuae105
8. Intermittent fasting and its impact on toxicities, symptoms and quality of life in patients on active cancer treatment.
   Li Sucholeiki R, Propst CL, Hong DS, George GC. · · 2024 · cited 4× · PMID 38574507 · DOI 10.1016/j.ctrv.2024.102725