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NCT05257655: GLOA-MRT
Ganglionic Local Opioid Analgesia at the Ganglion Cervicale Superius
NA trial testing MRI after ganglionic local opioid analgesia (GLOA) in Trigeminal Neuralgia, Idiopathic in 3 participants. Completed in 1 October 2023.
31 August 2023
Quick facts
| Lead sponsor | Klinikum Klagenfurt am Wörthersee |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 3 |
| Start date | 9 January 2023 |
| Primary completion | 31 August 2023 |
| Estimated completion | 1 October 2023 |
| Sites | 1 location across Austria |
Drugs / interventions tested
- MRI after ganglionic local opioid analgesia (GLOA)
Conditions studied
- Trigeminal Neuralgia, Idiopathic — all drugs for Trigeminal Neuralgia, Idiopathic →
- Postherpetic; Neuralgia, Trigeminal (Etiology) — all drugs for Postherpetic; Neuralgia, Trigeminal (Etiology) →
- Glossopharyngeal Neuralgia — all drugs for Glossopharyngeal Neuralgia →
- Atypical Facial Pain — all drugs for Atypical Facial Pain →
Sponsor
Klinikum Klagenfurt am Wörthersee
Who can join
18 and older, any sex, with Trigeminal Neuralgia, Idiopathic or Postherpetic; Neuralgia, Trigeminal (Etiology). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The blockade of the superior cervical ganglion (GCS) of the sympathetic trunk is a very special form of therapy. The transoral blocking technique, also known as GLOA (ganglionic local opioid analgesia), is very suitable for achieving GCS. A total of 5 μg of sufentanil in 2 ml of sodium chlorid are applied. Since no imaging evidence of the injected substances has been published for a GLOA in a living person, it is planned to carry out an MRI examination immediately after the ganglionic local opioid analgesia in order to show the spread and distribution pattern of the injected substance. It is also planed to show a correlation of the spread of the injected substance with the efficacy of the intervention. To determine the interrater reliability, the GLOA is carried out alternately by 2 different examiners and the existing MRI images of the GLOA are assessed by an radiologist and anatomist in a blinded manner. In a follow-up after 1 and 3 months, the questionnaires and pain scores are evaluated again.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05257655
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Trigeminal Neuralgia, Idiopathic
Currently open trials in the same condition.
- NCT06620172 — CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal Neuralgia · NA · recruiting
- NCT06472323 — The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for the Trigeminal Neuralgia · recruiting
Other Klinikum Klagenfurt am Wörthersee trials
Trials by the same sponsor.
- NCT06174324 — Visual Field Progression and RNFL Change After PreserFlo MicroShunt Implantation · unknown
- NCT03776019 — Efficacy of Audio-Visual-Perception-Enhancement (AVWF®) Method in Chronic Pain Patients · NA · completed
- NCT04168320 — SBRT-based PArtial Tumor Irradiation of HYpoxic Segment · Phase 1 · terminated
- NCT06160960 — Influence of Pupillary Behavior During Eye Surgery on Morphological and Functional Outcome · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05257655 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Klinikum Klagenfurt am Wörthersee
- Last refreshed: 3 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05257655.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing