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NCT05253937: (iCPR)
Impact of Intracoronary Versus Intravenous Epinephrine Administration During Cardiac Arrest .
trial testing Epinephrin in Cardiopulmonary Arrest in 160 participants. Completed in 1 June 2022.
1 June 2021
Quick facts
| Lead sponsor | Lithuanian University of Health Sciences |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 160 |
| Start date | 1 April 2018 |
| Primary completion | 1 June 2021 |
| Estimated completion | 1 June 2022 |
| Sites | 1 location across Lithuania |
Drugs / interventions tested
- Epinephrin — full drug profile →
Conditions studied
- Cardiopulmonary Arrest — all drugs for Cardiopulmonary Arrest →
- Epinephrine Causing Adverse Effects in Therapeutic Use — all drugs for Epinephrine Causing Adverse Effects in Therapeutic Use →
Sponsor
Lithuanian University of Health Sciences
Who can join
18 and older, any sex, with Cardiopulmonary Arrest or Epinephrine Causing Adverse Effects in Therapeutic Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In hospital cardiac arrest (IHCA) is a major challenge imposed on almost all health care systems worldwide. Despite significant progress in cardiopulmonary resuscitation in the past few years, outcomes remain relatively poor with an approximate 49 % survival rate. Epinephrine administration remains a cornerstone in the treatment of cardiac arrest. However, the preferred route of administration remains a matter of debate within the medical community . Various routes of administration, including intravenous, intramuscular, intraosseous and endotracheal routes have been studied. Initially, American guidelines for the treatment of cardiac arrest recommended injection of 0.5 mg of epinephrine directly into the right ventricle through the parasternal approach, aiming to achieve higher peak intracardiac concentrations and a more central effect, however the intravenous route remained preferable due to its feasibility and safety . To our knowledge, intra-coronary epinephrine administration for intraprocedural cardiac arrest has not been evaluated or compared with other routes of administration.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A prospective observational study on impact of epinephrine administration route on acute myocardial infarction patients with cardiac arrest in the catheterization laboratory (iCPR study).
Aldujeli A, Haq A, Tecson KM, Kurnickaite Z, et al · · 2022 · cited 2× · PMID 36539907 · DOI 10.1186/s13054-022-04275-8
Verify or expand the search:
- PubMed search for NCT05253937
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Currently open trials in the same condition.
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05253937 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lithuanian University of Health Sciences
- Last refreshed: 16 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05253937.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing