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NCT05247853
HPV Vaccine Effectiveness Study in Rwandan Women Living With HIV
trial testing Blood collection in Cervical Cancer in 3,127 participants. Completed in 12 December 2024.
12 December 2024
Quick facts
| Lead sponsor | Montefiore Medical Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 3,127 |
| Start date | 3 November 2021 |
| Primary completion | 12 December 2024 |
| Estimated completion | 12 December 2024 |
| Sites | 1 location across Rwanda |
Drugs / interventions tested
- Blood collection — full drug profile →
- Oral, cervicovaginal and anal specimen collection
- Anoscopy & Biopsy of Acetowhite Lesions
- Colposcopy & Biopsy of Acetowhite Lesions
- Ablative Treatment
- LEEP (Loop Electrosurgical Excision Procedure)
Conditions studied
- Cervical Cancer — all drugs for Cervical Cancer →
- Human Papilloma Virus — all drugs for Human Papilloma Virus →
- Human Immunodeficiency Virus — all drugs for Human Immunodeficiency Virus →
- HPV-Related Carcinoma — all drugs for HPV-Related Carcinoma →
Sponsor
Montefiore Medical Center
Who can join
Adults 18 to 28, female only, with Cervical Cancer or Human Papilloma Virus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Our study will assess and measure population effectiveness of prophylactic HPV vaccine in reducing cervical, anal, and/or oral prevalent and 6-month persistent infections among HPV-vaccinated and 757 HPV-unvaccinated Rwandan WLWH aged 18-26 years. Additional objectives include the quantification \& examination of long-term antibody (into young adulthood) responses to HPV vaccination and to validate the performance (e.g., sensitivity and specificity) of a low-cost, POC (point-of-care) anti-HPV16 antibody test to determine/confirm HPV vaccination status. The findings for this study will provide necessary evidence regarding the long-term protection afforded by HPV vaccination in WLWH living in SSA, who are at the greatest risk of HPV-related cancers.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
State-of-the-Science of human papillomavirus vaccination in women with human immunodeficiency Virus: Summary of a scientific workshop.
Schuind AE, Rees H, Schiller J, Mugo N, et al · · 2023 · cited 3× · PMID 37576844 · DOI 10.1016/j.pmedr.2023.102331
Verify or expand the search:
- PubMed search for NCT05247853
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Cervical Cancer
Currently open trials in the same condition.
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Other Montefiore Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05247853 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Montefiore Medical Center
- Last refreshed: 16 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05247853.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing