Last reviewed · How we verify
NCT05247424: UFH-STEMI
Pretreatment With Unfractionated Heparin for ST Elevation Myocardial Infarction
Phase 4 trial testing Unfractionated heparin in STEMI - ST Elevation Myocardial Infarction in 600 participants. Completed in 5 March 2025.
5 February 2025
Quick facts
| Lead sponsor | University Medical Centre Ljubljana |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 600 |
| Start date | 10 March 2022 |
| Primary completion | 5 February 2025 |
| Estimated completion | 5 March 2025 |
| Sites | 1 location across Slovenia |
Drugs / interventions tested
- Unfractionated heparin — full drug profile →
Conditions studied
- STEMI - ST Elevation Myocardial Infarction — all drugs for STEMI - ST Elevation Myocardial Infarction →
Sponsor
University Medical Centre Ljubljana
Who can join
18 and older, any sex, with STEMI - ST Elevation Myocardial Infarction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Rupture of a coronary artery plaque leads to thrombotic occlusion of the coronary artery and would present as ST segment elevation myocardial infarction. Early treatment with aspirin and early primary percutaneous coronary intervention are indicated. Anticoagulation therapy, usually with unfractionated heparin, is required during percutaneous coronary intervention. Investigators hypothesis is that pretreatment with unfractionated heparin in addition to aspirin at first medical contact may facilitate spontaneous reperfusion of culprit artery and procedural thrombotic complication in patients with ST elevation myocardial infarction without significant risk of bleeding complications.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Heparin pretreatment in STEMI: is earlier always better?
Collet JP, Zeitouni M. · · 2022 · cited 3× · PMID 36269208 · DOI 10.4244/eij-e-22-00035 -
Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN-STEMI Randomized Controlled Trial.
Fister M, Noc M, Radsel P, Bunc M, et al · · 2026 · cited 1× · PMID 41910504 · DOI 10.1161/circulationaha.126.079839 -
Early unfractionated heparin treatment in patients with STEMI - trial design and rationale.
Fister M, Mikuz U, Ziberna K, Franco D, et al · · 2024 · PMID 38723003 · DOI 10.1371/journal.pone.0303376
Verify or expand the search:
- PubMed search for NCT05247424
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Unfractionated heparin
Trials testing the same drug.
- NCT07361783 — Impact of Pre-Hospital Heparin Loading in STEMI Patients for Primary PCI: The HELP-PCI 2 Trial · NA · recruiting
- NCT06442267 — Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support · Phase 4 · recruiting
- NCT05959252 — BivaLirudin versUS Heparin in Extracorporeal Membrane Oxygenation · Phase 2 · recruiting
- NCT06174961 — The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin · Phase 4 · completed
- NCT05255848 — Nebulised Heparin in Patients With COVID-19 Pneumonia · Phase 2, PHASE3 · unknown
Other recruiting trials for STEMI - ST Elevation Myocardial Infarction
Currently open trials in the same condition.
- NCT07160491 — Early Thrombolysis Guided by AI-Assisted App in Patients With STEMI · NA · recruiting
- NCT06013020 — Century Clot-Guided Prophylactic Rivaroxaban for Post STEMI Complicating Left Ventricular Thrombus · Phase 4 · recruiting
- NCT06384846 — AI Algorithms in Prediction of ACS Based on Leukocyte Properties · recruiting
- NCT04436978 — What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI? · Phase 4 · recruiting
- NCT05800951 — Can Escalation Reduce Acute Myocardial Infarction Mortality in Cardiogenic Shock · active not recruiting
Other University Medical Centre Ljubljana trials
Trials by the same sponsor.
- NCT07466472 — Image-Guided Central Catheter Insertion With Concurrent Assessment of Vascular Wall Integrity · not yet recruiting
- NCT07446244 — Catheter Ablation of Advanced Forms of Atrial Fibrillation · NA · enrolling by invitation
- NCT07109076 — Effect of Immediate Skin-to-Skin Contact on Neonatal Heart Rate Variability After Cesarean Secton · NA · recruiting
- NCT07354880 — Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease · Phase 4 · not yet recruiting
- NCT07496736 — Post-exposure Influenza Prophylaxis in a Hospital Setting · Phase 3 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05247424 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Medical Centre Ljubljana
- Last refreshed: 1 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05247424.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing