Who is sponsoring NCT05243238?

NCT05243238 is sponsored by Beni-Suef University.

What drugs are being tested in NCT05243238?

Interventions in NCT05243238: dietary supplement flavonoids.

What condition does NCT05243238 study?

NCT05243238 studies Metabolic Syndrome and Diabetic Neuropathy.

Is NCT05243238 still recruiting?

NCT05243238 is currently completed. Last updated 17 February 2022.

Last reviewed 2022-02-17 · How we verify

NCT05243238

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hesperidin and Diosmin Effect on Metabolic Syndrome

Completed NA Last updated 17 February 2022

What this trial tests

NA trial testing dietary supplement flavonoids in Metabolic Syndrome and Diabetic Neuropathy in 129 participants. Completed in 12 November 2021.

Timeline

1 March 2020

Primary endpoint
30 November 2020

12 November 2021

Quick facts

Lead sponsor	Beni-Suef University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	129
Start date	1 March 2020
Primary completion	30 November 2020
Estimated completion	12 November 2021
Sites	1 location across Egypt

Drugs / interventions tested

dietary supplement flavonoids

Conditions studied

Metabolic Syndrome and Diabetic Neuropathy — all drugs for Metabolic Syndrome and Diabetic Neuropathy →

Sponsor

Beni-Suef University

Who can join

Adults 18 to 70, any sex, with Metabolic Syndrome and Diabetic Neuropathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The components of metabolic syndrome (MetS), particularly obesity and dyslipidemia, are linked to peripheral neuropathy (PN) among patients with diabetes or even without diabetes. Several studies revealed that complementary and herbal medicine could provide a potential for PN management and MetS components. Thus, designing clinical trials with interventions combinations to achieve a considerable improvement is highly recommended. Hesperidin and diosmin, citrus-derived flavonoids, have been reported to possess anti-hyperlipidemic, anti-inflammatory, analgesic, antioxidant, antidiabetic, and anti-hypertensive effect with high tolerability and safety profile

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Bioactivity and mechanisms of flavonoids in decreasing insulin resistance.
Zhou M, Konigsberg WH, Hao C, Pan Y, et al · · 2023 · cited 21× · PMID 37036026 · DOI 10.1080/14756366.2023.2199168
The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial.
Osama H, Hamed EO, Mahmoud MA, Abdelrahim MEA. · · 2023 · cited 17× · PMID 35946912 · DOI 10.1080/19390211.2022.2107138
Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids.
Mbara KC, Fotsing MCD, Ndinteh DT, Mbeb CN, et al · · 2024 · cited 10× · PMID 38846008 · DOI 10.1016/j.crphar.2024.100184

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05243238 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beni-Suef University
Last refreshed: 17 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05243238.

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