NCT05241431 (DAPAS) is a Phase 2, PHASE3 clinical trial of SGLT2 inhibitor in Aortic Stenosis, sponsored by University of Aarhus.

Who is sponsoring NCT05241431?

NCT05241431 is sponsored by University of Aarhus.

What drugs are being tested in NCT05241431?

Interventions in NCT05241431: SGLT2 inhibitor, Placebo.

What condition does NCT05241431 study?

NCT05241431 studies Aortic Stenosis, Left Ventricle Hypertrophied.

Is NCT05241431 still recruiting?

NCT05241431 is currently status unknown. Last updated 15 February 2022.

Last reviewed 2022-02-15 · How we verify

NCT05241431: DAPAS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention

Status unknown Phase 2, PHASE3 Last updated 15 February 2022

What this trial tests

Phase 2, PHASE3 trial testing SGLT2 inhibitor in Aortic Stenosis in 106 participants. Status unknown.

Timeline

12 February 2022

Primary endpoint
1 March 2024

1 April 2024

Quick facts

Lead sponsor	University of Aarhus
Phase	Phase 2, PHASE3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	106
Start date	12 February 2022
Primary completion	1 March 2024
Estimated completion	1 April 2024
Sites	1 location across Denmark

Drugs / interventions tested

SGLT2 inhibitor — full drug profile →
Placebo

Conditions studied

Aortic Stenosis — all drugs for Aortic Stenosis →
Left Ventricle Hypertrophied — all drugs for Left Ventricle Hypertrophied →

Sponsor

University of Aarhus

Who can join

Adults 18 to 85, any sex, with Aortic Stenosis or Left Ventricle Hypertrophied. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Randomized, double-blinded, placebo-controlled study in AS patients with subclinical or clinical heart failure undergoing treatment with TAVR.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits.
Preda A, Montecucco F, Carbone F, Carbone F, et al · · 2024 · cited 76× · PMID 38456601 · DOI 10.1093/cvr/cvae047

Verify or expand the search:

Other trials of SGLT2 inhibitor

Trials testing the same drug.

NCT07360457 — GLP1 Analogues and the Risk of Osteoarthritis · not yet recruiting
NCT07172971 — Sodium/Glucose Cotransporter-2 Inhibitors (SGLT2i) Therapy in Duchenne Cardiomyopathy · Phase 1 · not yet recruiting
NCT07334145 — Effect of SGLT2 Inhibitors on Anemic CKD Patients · not yet recruiting
NCT07063316 — SGLT2 Inhibitors and Renal Anemia in Japan: RWD · active not recruiting
NCT06350487 — The Efficacy of Enavogliflozin in Heart Failure With Preserved Ejection Fraction · Phase 4 · not yet recruiting

Other recruiting trials for Aortic Stenosis

Currently open trials in the same condition.

NCT07197736 — DELINEATE-Prospective · recruiting
NCT07230964 — Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacemen · NA · recruiting
NCT07205068 — Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and P · NA · recruiting
NCT07052071 — Impact of Transcatheter Aortic Valve Implantation (TAVI) on the Gut Microbiota in Patients With Aortic Valve Stenosis · recruiting
NCT07144189 — AI Assessment of Low-Gradient Aortic Stenosis Severity Based on Echocardiography · recruiting

Other University of Aarhus trials

Trials by the same sponsor.

NCT07209540 — European LUpuS Inception-Cohort Developing initiATivE · not yet recruiting
NCT07317401 — Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Post-Viral Myalgic Encephalo · NA · not yet recruiting
NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
NCT07528339 — Prospective RegIstry for Oncologic Reirradiation (PRIOR-DK) · not yet recruiting
NCT07451028 — Effect of an Oral Neuromuscular Training Device on Dysphagia · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05241431 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Aarhus
Last refreshed: 15 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05241431.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing