NCT05237128 (LEGEND) is a NA clinical trial of Very low-carbohydrate diet in Type 2 Diabetes, sponsored by University of Michigan.

Who is sponsoring NCT05237128?

NCT05237128 is sponsored by University of Michigan.

What drugs are being tested in NCT05237128?

Interventions in NCT05237128: Very low-carbohydrate diet, Moderate-carbohydrate plate-method diet.

What condition does NCT05237128 study?

NCT05237128 studies Type 2 Diabetes.

Is NCT05237128 still recruiting?

NCT05237128 is currently completed. Last updated 10 November 2025.

Last reviewed 2025-11-10 · How we verify

NCT05237128: LEGEND

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Lifestyle Education About Nutrition for Diabetes (Legend) Study

Completed NA Last updated 10 November 2025

What this trial tests

NA trial testing Very low-carbohydrate diet in Type 2 Diabetes in 182 participants. Completed in 1 October 2025.

Timeline

22 March 2022

Primary endpoint
1 October 2025

1 October 2025

Quick facts

Lead sponsor	University of Michigan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	182
Start date	22 March 2022
Primary completion	1 October 2025
Estimated completion	1 October 2025
Sites	2 locations across United States

Drugs / interventions tested

Very low-carbohydrate diet
Moderate-carbohydrate plate-method diet

Conditions studied

Type 2 Diabetes — all drugs for Type 2 Diabetes →

Sponsor

University of Michigan

Who can join

21 and older, any sex, with Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is being completed to compare two dietary approaches for participants with type 2 diabetes. This research will test whether a very low-carbohydrate or a plate-method diet better improves outcomes for blood glucose control and body composition for patients with type 2 diabetes that follow one of these approaches for 12 months. Participants that meet screening and eligibility will be randomized to one of the two diets. In addition to the diet, study specific visits and assessments will be performed at various timepoints.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Protocol for a randomized controlled trial comparing a very low-carbohydrate diet or moderate-carbohydrate plate-method diet for type 2 diabetes: the LEGEND (Lifestyle Education about Nutrition for Diabetes) trial.
Saslow LR, Eslamian A, Moran P, Hartogensis W, et al · · 2023 · PMID 37475033 · DOI 10.1186/s13063-023-07512-9

Verify or expand the search:

Other trials of Very low-carbohydrate diet

Trials testing the same drug.

NCT05452642 — The Supporting Understanding of PCOS Education and Research (SUPER) Study · NA · active not recruiting
NCT05235425 — The Lifestyle Education About Prediabetes (Leap) Study · NA · completed

Other recruiting trials for Type 2 Diabetes

Currently open trials in the same condition.

NCT07053319 — SGLT2i, Pioglitazone, and Ketone Production in T2D · Phase 1 · recruiting
NCT07272837 — Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass · recruiting
NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT07254689 — The Food for Health Study · NA · recruiting
NCT07558863 — Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes · Phase 4 · recruiting

Other University of Michigan trials

Trials by the same sponsor.

NCT07536919 — Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation · NA · not yet recruiting
NCT05509842 — Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD) · NA · not yet recruiting
NCT06311188 — Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness · NA · not yet recruiting
NCT07471646 — Effects of Ramadan Fasting With Exercise on Cardiometabolic Health · NA · not yet recruiting
NCT06671925 — A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05237128 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Michigan
Last refreshed: 10 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05237128.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing