Who is sponsoring NCT05235165?

NCT05235165 is sponsored by Children's Oncology Group.

What drugs are being tested in NCT05235165?

Interventions in NCT05235165: Biospecimen Collection, Computed Tomography, Questionnaire Administration, Thoracoscopy, Thoracotomy.

What condition does NCT05235165 study?

NCT05235165 studies Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma, Osteosarcoma.

Is NCT05235165 still recruiting?

NCT05235165 is currently recruiting now. Last updated 27 February 2026.

Last reviewed 2026-02-27 · How we verify

NCT05235165

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Recruiting now Phase 3 Last updated 27 February 2026

What this trial tests

Phase 3 trial testing Biospecimen Collection in Metastatic Malignant Neoplasm in the Lung in 62 participants. Currently enrolling.

Timeline

1 April 2022

Primary endpoint
31 March 2031

31 March 2031

Quick facts

Lead sponsor	Children's Oncology Group
Phase	Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	62
Start date	1 April 2022
Primary completion	31 March 2031
Estimated completion	31 March 2031
Sites	232 locations across New Zealand, Saudi Arabia, Canada, Puerto Rico, Australia, United States

Drugs / interventions tested

Biospecimen Collection — full drug profile →
Computed Tomography
Questionnaire Administration
Thoracoscopy
Thoracotomy

Conditions studied

Metastatic Malignant Neoplasm in the Lung — all drugs for Metastatic Malignant Neoplasm in the Lung →
Metastatic Osteosarcoma — all drugs for Metastatic Osteosarcoma →
Osteosarcoma — all drugs for Osteosarcoma →

Sponsor

Children's Oncology Group — full company profile →

Who can join

Under 50, any sex, with Metastatic Malignant Neoplasm in the Lung or Metastatic Osteosarcoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Inclusion of a core patient-reported outcomes battery in adolescent and young adult cancer clinical trials.
Roth ME, Parsons SK, Ganz PA, Wagner LI, et al · · 2023 · cited 34× · PMID 36266760 · DOI 10.1093/jnci/djac166
Children's Oncology Group's 2023 blueprint for research: Bone tumors.
Reed DR, Grohar P, Rubin E, Binitie O, et al · · 2023 · cited 15× · PMID 37501549 · DOI 10.1002/pbc.30583
Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma.
Kuo C, Malvar J, Chi YY, Kim ES, et al · · 2023 · cited 11× · PMID 37800658 · DOI 10.1002/cam4.6491
Children's Oncology Group's 2023 blueprint for research: Surgery.
Gow KW, Lautz TB, Malek MM, Cost NG, et al · · 2024 · cited 7× · PMID 37950538 · DOI 10.1002/pbc.30766
Incorporation of patient-reported outcomes in pediatric cancer clinical trials: design, implementation, and dissemination.
Greenzang KA, Montgomery KE, DuVall A, Roth ME, et al · · 2025 · cited 1× · PMID 40163691 · DOI 10.1093/jnci/djaf083
Considerations for Clinical Trial Design in Relapsed and Refractory Osteosarcoma: An FDA Symposium.
Wessel KM, Janeway KA, Davis LE, Drezner N, et al · · 2026 · PMID 41481339 · DOI 10.1158/1078-0432.ccr-25-3282

Verify or expand the search:

Other trials of Biospecimen Collection

Trials testing the same drug.

NCT07229339 — Zipalertinib With Carboplatin and Pemetrexed for the Treatment of Resectable, Stage II-IIIB, Non-Small Cell Lung Cancer · Phase 2 · not yet recruiting
NCT07441681 — Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive · Phase 3 · not yet recruiting
NCT07365306 — Epcoritamab, Rituximab, Gemcitabine and Oxaliplatin (R-GemOx) as Salvage Therapy Before Autologous Stem Cell Transplant · Phase 2 · not yet recruiting
NCT07147231 — Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cem · Phase 1, PHASE2 · recruiting
NCT07572123 — Evaluating the Addition of Maintenance Immunotherapy Compared to the Usual Treatment of Chemotherapy and Autologous Stem · Phase 2, PHASE3 · not yet recruiting

Other recruiting trials for Metastatic Malignant Neoplasm in the Lung

Currently open trials in the same condition.

NCT06482073 — Molecular Analysis of Suspected or High-Risk Lung Cancer to Drive Individualized Care (Interception for Suspected Lung C · recruiting
NCT05802186 — Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of · NA · recruiting
NCT05039632 — Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (An · Phase 1, PHASE2 · recruiting
NCT03965234 — Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases · Phase 1, PHASE2 · recruiting
NCT03422302 — Continuous Positive Airway Pressure Device or Deep Inspiration Breath Hold in Reducing Tumor Motion in Patients Undergoi · NA · recruiting

Other Children's Oncology Group trials

Trials by the same sponsor.

NCT07412002 — Quality of End-of-Life Care for Children With Cancer · not yet recruiting
NCT07498465 — A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant · Phase 1 · withdrawn
NCT07022678 — Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia · Phase 3 · not yet recruiting
NCT07072585 — Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leuk · Phase 2, PHASE3 · not yet recruiting
NCT06858501 — Comparing 123I-MIBG and 18F-MFBG Imaging in Patients With Newly Diagnosed, High Risk Neuroblastoma · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05235165 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Children's Oncology Group
Last refreshed: 27 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05235165.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing