NCT05234762 is a Phase 2 clinical trial of ES-481 in Tremor, Essential, sponsored by ES Therapeutics Australia Pty Ltd.

Who is sponsoring NCT05234762?

NCT05234762 is sponsored by ES Therapeutics Australia Pty Ltd.

What drugs are being tested in NCT05234762?

Interventions in NCT05234762: ES-481, Placebo.

What condition does NCT05234762 study?

NCT05234762 studies Tremor, Essential.

Is NCT05234762 still recruiting?

NCT05234762 is currently status unknown. Last updated 2 March 2023.

Last reviewed 2023-03-02 · How we verify

NCT05234762

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy, Safety, and Pharmacokinetics of ES-481 in Adult Patients With Essential Tremors

Status unknown Phase 2 Last updated 2 March 2023

What this trial tests

Phase 2 trial testing ES-481 in Tremor, Essential in 24 participants. Status unknown.

Timeline

21 November 2021

Primary endpoint
31 December 2023

31 December 2023

Quick facts

Lead sponsor	ES Therapeutics Australia Pty Ltd
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	24
Start date	21 November 2021
Primary completion	31 December 2023
Estimated completion	31 December 2023
Sites	1 location across Canada

Drugs / interventions tested

ES-481 — full drug profile →
Placebo

Conditions studied

Tremor, Essential — all drugs for Tremor, Essential →

Sponsor

ES Therapeutics Australia Pty Ltd — full company profile →

Who can join

Adults 18 to 75, any sex, with Tremor, Essential. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This Pilot Phase 2A study will investigate the safety, tolerability, and pharmacokinetics (PK) of ES-481 in adult patients with essential tremor.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies.
Mukherjee A, Pandey S. · · 2025 · cited 5× · PMID 40415659 · DOI 10.1002/mdc3.70147

Verify or expand the search:

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05234762 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by ES Therapeutics Australia Pty Ltd
Last refreshed: 2 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05234762.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing