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NCT05234697
Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids
trial testing Remifentanil in Postoperative Hyperalgesia in 60 participants. Completed in 20 May 2022.
20 May 2022
Quick facts
| Lead sponsor | The Second Affiliated Hospital of Chongqing Medical University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 12 January 2022 |
| Primary completion | 20 May 2022 |
| Estimated completion | 20 May 2022 |
| Sites | 1 location across China |
Drugs / interventions tested
- Remifentanil — full drug profile →
Conditions studied
- Postoperative Hyperalgesia — all drugs for Postoperative Hyperalgesia →
Sponsor
The Second Affiliated Hospital of Chongqing Medical University
Who can join
Adults 18 to 65, any sex, with Postoperative Hyperalgesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were respectively included. Postoperative hyperalgesia at PACU and 24 hours after surgery were assessed through mechanical pain measurement. Comparative analysis of postoperative hyperalgesia levels, pain and analgesic requirements between morning group and afternoon group were performed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Opioid infusions at different times of the day produce varying degrees of opioid-induced hyperalgesia.
Shu B, Liu H, Zheng X, He J, et al · · 2023 · cited 2× · PMID 37821342 · DOI 10.1016/j.bja.2023.08.039
Verify or expand the search:
- PubMed search for NCT05234697
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05234697 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Second Affiliated Hospital of Chongqing Medical University
- Last refreshed: 28 December 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05234697.
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