NCT05234203

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age

Completed NA Last updated 6 December 2022

What this trial tests

NA trial testing HTB Rejuvenate in Immunity Disorders in 50 participants. Completed in 7 October 2022.

Timeline

25 March 2022

Primary endpoint
7 October 2022

7 October 2022

Quick facts

Lead sponsor	Big Bold Health, PBC
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	50
Start date	25 March 2022
Primary completion	7 October 2022
Estimated completion	7 October 2022
Sites	1 location across United States

Drugs / interventions tested

• HTB Rejuvenate

Conditions studied

• Immunity Disorders — all drugs for Immunity Disorders →
• Aging — all drugs for Aging →
• Inflammation — all drugs for Inflammation →

Sponsor

Big Bold Health, PBC

Who can join

Adults 18 to 85, any sex, with Immunity Disorders or Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Epigenetic regulation of aging: implications for interventions of aging and diseases.
   Wang K, Liu H, Hu Q, Wang L, et al · · 2022 · cited 406× · PMID 36336680 · DOI 10.1038/s41392-022-01211-8
2. Human age reversal: Fact or fiction?
   Johnson AA, English BW, Shokhirev MN, Sinclair DA, et al · · 2022 · cited 56× · PMID 35778957 · DOI 10.1111/acel.13664
3. Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging - from theory to practice.
   Luís C, Maduro AT, Pereira P, Mendes JJ, et al · · 2022 · cited 29× · PMID 36159455 · DOI 10.3389/fnut.2022.958563
4. The impact of a polyphenol-rich supplement on epigenetic and cellular markers of immune age: a pilot clinical study.
   Perlmutter A, Bland JS, Chandra A, Malani SS, et al · · 2024 · cited 4× · PMID 39628466 · DOI 10.3389/fnut.2024.1474597
5. Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events.
   Santos TWD, Pereira QC, Fortunato IM, Oliveira FS, et al · · 2024 · cited 4× · PMID 39519454 · DOI 10.3390/nu16213621