NCT05230914

A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)

Recruiting now NA Last updated 26 December 2025

What this trial tests

NA trial testing Simplified imaging strategy in Stroke, Ischemic in 1,846 participants. Currently enrolling.

Timeline

12 December 2024

Primary endpoint
30 June 2027

31 October 2027

Quick facts

Lead sponsor	Xinqiao Hospital of Chongqing
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	1,846
Start date	12 December 2024
Primary completion	30 June 2027
Estimated completion	31 October 2027
Sites	8 locations across China

Drugs / interventions tested

• Simplified imaging strategy
• Standard imaging strategy

Conditions studied

• Stroke, Ischemic — all drugs for Stroke, Ischemic →
• Stroke, Acute — all drugs for Stroke, Acute →

Sponsor

Xinqiao Hospital of Chongqing

Who can join

18 and older, any sex, with Stroke, Ischemic or Stroke, Acute. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy.

The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Neuroimaging of Acute Ischemic Stroke: Multimodal Imaging Approach for Acute Endovascular Therapy.
   Abdalkader M, Siegler JE, Lee JS, Yaghi S, et al · · 2023 · cited 50× · PMID 36746380 · DOI 10.5853/jos.2022.03286
2. Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee.
   Nguyen TN, Castonguay AC, Siegler JE, Nagel S, et al · · 2023 · cited 31× · PMID 39380893 · DOI 10.1161/svin.122.000512
3. Perfusion vs non-perfusion computed tomography imaging in the late window of emergent large vessel ischemic stroke: A systematic review and meta-analysis.
   Diestro JDB, Omar AT, Zhang YQ, Kishibe T, et al · · 2024 · cited 9× · PMID 38166040 · DOI 10.1371/journal.pone.0294127
4. Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey.
   Nguyen TN, Klein P, Berberich A, Nagel S, et al · · 2023 · cited 2× · PMID 41585765 · DOI 10.1161/svin.122.000595
5. Clinical Uncertainty in Large Vessel Occlusion ischemic stroke (CULVO): Does automated perfusion scanning make a difference? Protocol of an intrarater and interrater agreement study.
   Diestro JDB, Fahed R, Benomar A, Omar AT, et al · · 2024 · cited 2× · PMID 38289912 · DOI 10.1371/journal.pone.0297520
6. Selection by Noncontrast Computed Tomography With or Without Computed Tomography Angiography Versus Computed Tomography Perfusion for Endovascular Therapy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
   Zhang Y, Zhao Y, Deng B, Wu S, et al · · 2025 · cited 1× · PMID 40497499 · DOI 10.1161/jaha.124.038173