Last reviewed · How we verify
NCT05230472
Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia
Phase 4 trial testing Simvastatin in VAP - Ventilator Associated Pneumonia in 161 participants. Completed in 1 February 2022.
20 December 2021
Quick facts
| Lead sponsor | Ain Shams University |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 161 |
| Start date | 1 January 2021 |
| Primary completion | 20 December 2021 |
| Estimated completion | 1 February 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Simvastatin (simvastatin) — full drug profile →
Conditions studied
- VAP - Ventilator Associated Pneumonia — all drugs for VAP - Ventilator Associated Pneumonia →
Sponsor
Ain Shams University
Who can join
Adults 29 to 71, any sex, with VAP - Ventilator Associated Pneumonia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Statins with their powerful anti-inflammatory, immunomodulatory, and antioxidant properties make them candidate members to be used in the management of sepsis and different types of infections including pneumonia. This study aims to determine whether adjunctive statin therapy decreased day- 28 mortality among ICU patients with ventilator-associated pneumonia (VAP) \& number of ventilator-free days (after successful weaning) between day 1 and both day 28.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05230472
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for VAP - Ventilator Associated Pneumonia
Currently open trials in the same condition.
- NCT06662630 — Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients · NA · recruiting
- NCT05952648 — HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array · NA · recruiting
Other Ain Shams University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05230472 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
- Last refreshed: 9 February 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05230472.
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