NCT05229380 is a clinical trial of Saccharin test in Eustachian Tube Dysfunction, sponsored by Assiut University.

Who is sponsoring NCT05229380?

NCT05229380 is sponsored by Assiut University.

What drugs are being tested in NCT05229380?

Interventions in NCT05229380: Saccharin test.

What condition does NCT05229380 study?

NCT05229380 studies Eustachian Tube Dysfunction.

Is NCT05229380 still recruiting?

NCT05229380 is currently status unknown. Last updated 8 February 2022.

Last reviewed 2022-02-08 · How we verify

NCT05229380

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pretympanoplasty Assessment of Patency and Mucociliary Function of Eustachian Tube

Status unknown Last updated 8 February 2022

What this trial tests

trial testing Saccharin test in Eustachian Tube Dysfunction in 50 participants. Status unknown.

Timeline

28 February 2022

Primary endpoint
31 December 2022

31 January 2023

Quick facts

Lead sponsor	Assiut University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	50
Start date	28 February 2022
Primary completion	31 December 2022
Estimated completion	31 January 2023

Drugs / interventions tested

Saccharin test — full drug profile →

Conditions studied

Eustachian Tube Dysfunction — all drugs for Eustachian Tube Dysfunction →

Sponsor

Assiut University

Who can join

Adults 18 to 65, any sex, with Eustachian Tube Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The eustachian tube (ET) performs three primary functions: pressure equalisation between the nasopharyms and middle ear: clearance of mucus from the middle ear, and prevention of sound or fluid reflux from the nasopharynx(1) .In individuals suffering from custachian tube dysunction (ETD), the tube opening may be obstructed(2) resulting in the typical complaints of ear fullness, muffled hearing, or tinnitus(3). Less frequently, the ET may be permanently patulous, resulting in the symptoms of aural pressure or autophony (4). Adequate Eustachian tube function (ETF) is necessary for successful middle ear surgery. Studies of eustachian tube patency have been studied by the Politzer, Valsalva, and Toynbee maneuvers. In other cases it has been accomplished by testing air transport through the eustachian tube by tympanometry, sonotubometry, and air pressure equalization technique. However, these methods do not evaluate the drainage function (5). Saccharin is a nonnutritive sweetener. It has property of being inert to respiratory epithelium that is it does not hamper physiological mucus clearance of sino-nasal mucosa. It can be used to assess mucocilliary function of nasal mucosa, without itself hampering it. The saccharin test seems to provide adequate information of the mucociliary function and patency of the ET (6) . Methylene blue is a chemical compound. It can be used to check patency of (ET). The dye, because of its liquid form, gravitates through the ET to the nasopharynx. So the objective of the dye is to establish the anatomical presence or absence of tube patency.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Eustachian Tube Dysfunction

Currently open trials in the same condition.

NCT07236580 — Buteyko Breathing and Approach of Smoking Hygiene: Effects on Dysfucntion of Eustachian Tube and Lung Functions · NA · recruiting
NCT07193485 — Efficacy of Buteyko Breathing in Seniors With Chronic Eustachian Tube Dysfunction · NA · recruiting
NCT05719207 — Efficacy of Balloon Dilation of the Eustachian Tube in Eustachian Tube Dilatory Dysfunction · NA · recruiting
NCT05275686 — Effect of Novel Exhalational Delivery System With Fluticasone (EDS-FLU) on Eustachian Tube Dysfunction (ETD) · Phase 2 · recruiting
NCT04645511 — Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis. · NA · recruiting

Other Assiut University trials

Trials by the same sponsor.

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NCT07194863 — Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD · not yet recruiting
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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05229380 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Assiut University
Last refreshed: 8 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05229380.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing