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NCT05229341
Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules
NA trial testing Diagnostic Procedure in Thyroid Gland Carcinoma in 1,450 participants. Currently enrolling.
22 October 2026
Quick facts
| Lead sponsor | City of Hope Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 1,450 |
| Start date | 22 October 2021 |
| Primary completion | 22 October 2026 |
| Estimated completion | 22 October 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Diagnostic Procedure
- Electronic Health Record Review
- Needle Biopsy
Conditions studied
- Thyroid Gland Carcinoma — all drugs for Thyroid Gland Carcinoma →
Sponsor
City of Hope Medical Center
Who can join
18 and older, any sex, with Thyroid Gland Carcinoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05229341
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other City of Hope Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05229341 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by City of Hope Medical Center
- Last refreshed: 23 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05229341.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing