NCT05227807 is a NA clinical trial of mouth opening exercise in Head and Neck Neoplasms, sponsored by National Taipei University of Nursing and Health Sciences.

Who is sponsoring NCT05227807?

NCT05227807 is sponsored by National Taipei University of Nursing and Health Sciences.

What drugs are being tested in NCT05227807?

Interventions in NCT05227807: mouth opening exercise, Usual care.

What condition does NCT05227807 study?

NCT05227807 studies Head and Neck Neoplasms.

Is NCT05227807 still recruiting?

NCT05227807 is currently completed. Last updated 7 February 2022.

Last reviewed 2022-02-07 · How we verify

NCT05227807

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Efficacy of Mouth Exercise in Oral Cancer Patients After Receiving Surgery

Completed NA Last updated 7 February 2022

What this trial tests

NA trial testing mouth opening exercise in Head and Neck Neoplasms in 69 participants. Completed in 12 December 2014.

Timeline

7 July 2012

Primary endpoint
30 October 2014

12 December 2014

Quick facts

Lead sponsor	National Taipei University of Nursing and Health Sciences
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	69
Start date	7 July 2012
Primary completion	30 October 2014
Estimated completion	12 December 2014

Drugs / interventions tested

mouth opening exercise
Usual care

Conditions studied

Head and Neck Neoplasms — all drugs for Head and Neck Neoplasms →

Sponsor

National Taipei University of Nursing and Health Sciences

Who can join

18 and older, any sex, with Head and Neck Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

PURPOSE: The purpose of the study was to investigate the efficacy of mouth-opening training with follow-up on 1st、3rd、6th months for reducing postoperative trismus in patients with oral cancer. METHODS: The study is a quasi-experimental design using repeated measures. 44 patients admitted at a general hospital in Taiwan for oral cancer surgery were recruited to the control group first then 38 patients were recruited to the intervention group. All subjects were instructed to practice mouth-opening exercises three times a day every day for three months and two telephone calls fellow up. Subjects in the intervention group received mouth-opening exercise adherence. Data on maximum interincisal opening and mandibular function impairment were collected before surgery, at one month, three months, and six months after radiotherapy, using the TheraBite Range-of-Motion scale and Mandibular Function Impairment Questionnaire, Restriction of Mouth Opening Questionnaire, and Difficulty of Food Intake.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effect of Oral Exercise on Trismus after Oral Cancer Radiotherapy: A Quasi-Experimental Study.
Wang TJ, Wu KF, Wang HM, Liang SY, et al · · 2022 · cited 3× · PMID 36428519 · DOI 10.3390/biomedicines10112951

Verify or expand the search:

Other recruiting trials for Head and Neck Neoplasms

Currently open trials in the same condition.

NCT07491536 — Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis · NA · recruiting
NCT06912087 — Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC · Phase 1 · recruiting
NCT06998069 — Head and Neck Cancer Study Project in the Geriatric Population · Phase 3 · recruiting
NCT07158164 — DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment · Phase 4 · recruiting
NCT06303180 — NIDCD Otolaryngology Clinical Protocol Biospecimen Bank · recruiting

Other National Taipei University of Nursing and Health Sciences trials

Trials by the same sponsor.

NCT07586696 — Effects of Exercise Board Games on Cognitive Function in Older Adults · NA · active not recruiting
NCT07243717 — Information-Assisted Intervention for Potential Living Kidney Donors · NA · recruiting
NCT07302568 — Exercise and Gezaixi Interventions on Community-Dwelling Older Adults · NA · completed
NCT07196488 — Dyadic Co-learning Intervention for Patients With Prostate Cancer and Their Spouses · NA · recruiting
NCT07086261 — Using SRT to Improve The Drinking Problem Behavior of Elderly People With Dementia During The Care of Day Care · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05227807 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Taipei University of Nursing and Health Sciences
Last refreshed: 7 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05227807.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing