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NCT05220995

The Effects of Miminal Stimulation Protocol on Preimplantation Genetic Screening

Status unknown Last updated 2 February 2022
What this trial tests

trial testing protocol in Preimplantation Genetic Screening in 200 participants. Status unknown.

Timeline
15 May 2021
Primary endpoint
23 January 2022
25 January 2022

Quick facts

Lead sponsorGokalp Oner
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment200
Start date15 May 2021
Primary completion23 January 2022
Estimated completion25 January 2022
Sites2 locations across Turkey (Türkiye)

Drugs / interventions tested

Conditions studied

Sponsor

Gokalp Oner

Who can join

Adults 38 to 45, female only, with Preimplantation Genetic Screening. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

PGS has been the most effective method for embryo selection in IVF cycles. Euploidy rates decrease significantly with advancing maternal age (AMA). The dosage of gonadotropins also may be increased to recruit an adequate number of follicles in AMA women, minimal Stimulation Protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) for controlled ovarian hyperstimulation is defined for poor ovarian response women. The aim of this study is to show minimal stimulation protocol affect euploidy and pregnancy rates in preimplatation genetic screening (PGS) cycles with single embryo transfer.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. The Effects of Minimal Stimulation Protocol on Preimplantation Genetic Screening.
    Oner G, Karaman E, Elmali F, Altmisyedioglu S, et al · · 2025 · PMID 40566030 · DOI 10.3390/jcm14124285

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