NCT05217433

Oleuropein and Muscle Energy Metabolism

Completed NA Last updated 17 March 2023

What this trial tests

NA trial testing Olive leaf extract in Muscular Fatigue in 40 participants. Completed in 10 March 2023.

Timeline

4 November 2021

Primary endpoint
10 March 2023

10 March 2023

Quick facts

Lead sponsor	Société des Produits Nestlé (SPN)
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	other
Enrollment	40
Start date	4 November 2021
Primary completion	10 March 2023
Estimated completion	10 March 2023
Sites	1 location across Netherlands

Drugs / interventions tested

• Olive leaf extract
• Placebo

Conditions studied

• Muscular Fatigue — all drugs for Muscular Fatigue →

Sponsor

Société des Produits Nestlé (SPN) — full company profile →

Who can join

Adults 50 to 70, male only, with Muscular Fatigue. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Preclinical studies performed at Nestlé Research (NR) identified oleuropein as a novel activator of mitochondrial calcium import. This potentiated mitochondrial calcium uptake resulted in decreased phosphorylation of the enzyme pyruvate dehydrogenase (PDH), which is linked to its activation as a rate limiting enzyme for mitochondrial oxidation, as well as increasing mitochondrial oxygen consumption, resulting ultimately in decreases in muscle fatigue. In addition, NR demonstrated that during aging, mitochondrial calcium and oxygen consumption rates are decreased in isolated skeletal muscle fibers. The next step in the evidence development is to demonstrate efficacy of oleuropein for improved muscle energy and decreased physical fatigue in a healthy aging population.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Oleuropein Supplementation Increases Resting Skeletal Muscle Fractional Pyruvate Dehydrogenase Activity but Does Not Influence Whole-Body Metabolism: A Randomized, Double-Blind, and Placebo-Controlled Trial in Healthy, Older Males.
   Pinckaers PJ, Petrick HL, Horstman AM, Moreno-Asso A, et al · · 2025 · cited 5× · PMID 39993475 · DOI 10.1016/j.tjnut.2025.02.015
2. Oleuropein Supplementation Increases Resting Skeletal Muscle Fractional Pyruvate Dehydrogenase Activity but Does Not Influence Whole-Body Metabolism: A Randomized, Double-Blind, and Placebo-Controlled Trial in Healthy, Older Males
   Pinckaers PJ, Petrick HL, Horstman AM, Moreno-Asso A, et al · · 2025