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NCT05217043: SYNTAXE
Language Acquisition in the Brain and Algorithms: Towards Systematic Monitoring of the Evolution of Semantic Representations in Biological and Artificial Neural Networks
trial testing intracranial brain recording in Language Acquisition in the Brain in 100 participants. Currently enrolling.
15 February 2027
Quick facts
| Lead sponsor | Fondation Ophtalmologique Adolphe de Rothschild |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 15 July 2022 |
| Primary completion | 15 February 2027 |
| Estimated completion | 15 February 2027 |
| Sites | 1 location across France |
Drugs / interventions tested
- intracranial brain recording
Conditions studied
- Language Acquisition in the Brain — all drugs for Language Acquisition in the Brain →
Sponsor
Fondation Ophtalmologique Adolphe de Rothschild — full company profile →
Who can join
18 and older, any sex, with Language Acquisition in the Brain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Speech depends on our ability to recursively combine successive words into a complex sense. Although the order of these putative operations (syntax) has been the subject of extensive examination in the way in which the human brain learns to perform a "Semantic composition" remains largely unknown. The Rothschild Hospital houses a unit specializing in drug-resistant epilepsy in children from 2 to 20 years old. The identification of the epileptogenic zone often requires making an iEEG recording for a week (implantation of intracerebral electrodes in depth). Sometimes this recording has to be repeated, providing a unique opportunity to directly record brain activity at different periods of its development. Children will listen to pre-recorded phrases and stories such as "The Little Prince of Antoine de Saint-Exupéry" while being recorded with iEEG.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05217043
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05217043 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondation Ophtalmologique Adolphe de Rothschild
- Last refreshed: 5 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05217043.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing