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NCT05216068
Investigation and Diagnosis of the Chromosome Variation in Donated/abandoned Blastocyst
NA trial testing NGS in Chromosome Translocation in 57 participants. Completed in 30 November 2024.
30 November 2024
Quick facts
| Lead sponsor | Chang Gung Memorial Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 57 |
| Start date | 1 December 2021 |
| Primary completion | 30 November 2024 |
| Estimated completion | 30 November 2024 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- NGS — full drug profile →
Conditions studied
- Chromosome Translocation — all drugs for Chromosome Translocation →
- Genetic Disorders in Pregnancy — all drugs for Genetic Disorders in Pregnancy →
- Recurrent Miscarriage — all drugs for Recurrent Miscarriage →
Sponsor
Chang Gung Memorial Hospital
Who can join
Adults 20 to 50, female only, with Chromosome Translocation or Genetic Disorders in Pregnancy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Blastocysts derived from patients seeking infertility treatment were generated by in vitro fertilization and embryo culture as previously described, and were evaluated using the Gardner system. As part of the embryo selection process, cells of TE biopsy were collected, and blastocysts were vitrified. The clinical TE biopsies were subjected to whole genome amplification (WGA) with SurePlex reagents (Illumina) followed by NGS-based PGT-A using Illumina's VeriSeq kit (Illumina) on a MiSeq system (Illumina) according to the manufacturer's protocol.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05216068
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Chang Gung Memorial Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05216068 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chang Gung Memorial Hospital
- Last refreshed: 20 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05216068.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing