Last reviewed · How we verify
NCT05211661: DAM
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
trial testing Respiratory Muscle Testing in Diaphragm Issues in 15 participants. Currently enrolling.
1 May 2028
Quick facts
| Lead sponsor | RWTH Aachen University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 15 |
| Start date | 10 October 2022 |
| Primary completion | 1 May 2028 |
| Estimated completion | 1 June 2028 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Respiratory Muscle Testing
Conditions studied
- Diaphragm Issues — all drugs for Diaphragm Issues →
- Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →
- Respiratory Failure — all drugs for Respiratory Failure →
- Intensive Care (ICU) Myopathy — all drugs for Intensive Care (ICU) Myopathy →
Sponsor
RWTH Aachen University
Who can join
Adults 18 to 75, any sex, with Diaphragm Issues or Mechanical Ventilation Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time. Through measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD. Paired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex. Against that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05211661
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other RWTH Aachen University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05211661 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by RWTH Aachen University
- Last refreshed: 9 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05211661.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing