NCT05209659

Applying Pain Adaptability to Manual Therapy Practice

Status unknown Last updated 29 September 2022

What this trial tests

trial testing Pragmatic Mobilization in Musculoskeletal Manipulations in 32 participants. Status unknown.

Timeline

15 February 2022

Primary endpoint
17 December 2022

31 December 2022

Quick facts

Lead sponsor	Youngstown State University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	32
Start date	15 February 2022
Primary completion	17 December 2022
Estimated completion	31 December 2022
Sites	3 locations across United States

Drugs / interventions tested

• Pragmatic Mobilization

Conditions studied

• Musculoskeletal Manipulations — all drugs for Musculoskeletal Manipulations →
• Low Back Pain — all drugs for Low Back Pain →

Sponsor

Youngstown State University

Who can join

18 and older, any sex, with Musculoskeletal Manipulations or Low Back Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Mechanism research has identified pain adaptive and non-adaptive phenotypes by documenting the response to an ice immersion bath. Pain adaptive individuals exhibited a rapid response to cold and a rapid resolution of symptoms with continued exposure. Non-pain adaptive individuals had the opposite. Pain-adaptive individuals have the endogenous (internal) capacity to self-modulate pain therefore may pursue active self management techniques, whereas non-pain adaptive phenotypes may be more prone to use of external mechanisms (e.g., analgesic medications) for pain relief. A pain adaptive individual is likely to benefit from all forms of conservative active or passive pain modulatory treatments and is expected to have a favorable prognosis. Although this finding is useful, ice bath immersion is an impractical assessment for clinical practice, leaving clinicians with the inability to identify pain adaptive individuals.

Emerging evidence indicates that an associative clinical response associated with an early within session (during the first visit) and between session (from the first to the second visit) during a posterior to anterior mobilization, identifies individuals who have a favorable prognosis with spinal pain. While neurophysiological basis for the analgesic effect of manual therapy has been proposed to date no one has investigated if the associative clinical response is purely another way of identifying pain adaptive or non-pain adaptive individuals. If a within-session or between-session response is associated with the pain adaptive mechanism found during an ice-bath immersion, clinicians could adopt the clinical evaluation technique and improve their ability to identify proper patients for management. The investigators will evaluate the relationship between the pain adaptive mechanistic response from ice-bath immersion and the associative clinical response that occurs during a PA mobilization of the spine.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.