Who is sponsoring NCT05208801?

NCT05208801 is sponsored by Yonsei University.

What drugs are being tested in NCT05208801?

Interventions in NCT05208801: Percutaneous injection, Morphine, Morphine+Bupivacaine.

What condition does NCT05208801 study?

NCT05208801 studies Patients Receiving Hepatectomy Under General Anesthesia.

Is NCT05208801 still recruiting?

NCT05208801 is currently completed. Last updated 26 January 2022.

Last reviewed 2022-01-26 · How we verify

NCT05208801

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Analgesic Effect of Intrathecal Morphine Combined With Low Dose Local Anesthetics on Postoperative Analgesia After Liver Resection

Completed NA Last updated 26 January 2022

What this trial tests

NA trial testing Percutaneous injection in Patients Receiving Hepatectomy Under General Anesthesia in 90 participants. Completed in 18 April 2020.

Timeline

19 November 2018

Primary endpoint
18 April 2020

18 April 2020

Quick facts

Lead sponsor	Yonsei University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	factorial
Masking	double
Primary purpose	treatment
Enrollment	90
Start date	19 November 2018
Primary completion	18 April 2020
Estimated completion	18 April 2020
Sites	1 location across South Korea

Drugs / interventions tested

Percutaneous injection — full drug profile →
Morphine
Morphine+Bupivacaine — full drug profile →

Conditions studied

Patients Receiving Hepatectomy Under General Anesthesia — all drugs for Patients Receiving Hepatectomy Under General Anesthesia →

Sponsor

Yonsei University

Who can join

19 and older, male only, with Patients Receiving Hepatectomy Under General Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Efficient postoperative pain control plays a vital part in the management of patients after surgery. In particular, major surgeries including hepatectomy cause intense postoperative pain that may result in cardiovascular or respiratory complications post-surgery. One of the current methods of postoperative pain control after hepatectomy involves a multimodal approach including intrathecal morphine injection immediately prior to surgery. Because morphine alone is inadequate for immediate postoperative pain control due to a late peak effect time of 6 hours, current literature advocates a combination injection including bupivacaine. However, higher doses of bupivacaine may inadvertently cause motor block or hemodynamic side effects. The aim of this study was to compare the effectiveness and side effects of intrathecal morphine combined with low dose bupivacaine against intrathecal morphine alone and no intrathecal injection.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Analgesic Effect of Intrathecal Morphine Combined with Low-Dose Bupivacaine on Postoperative Analgesia after Liver Resection: A Randomized Controlled Study.
Ban M, Choi YS, Koo BN. · · 2022 · cited 4× · PMID 35207699 · DOI 10.3390/jpm12020211

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05208801 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yonsei University
Last refreshed: 26 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05208801.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing