Who is sponsoring NCT05207059?

NCT05207059 is sponsored by KK Women's and Children's Hospital.

What drugs are being tested in NCT05207059?

Interventions in NCT05207059: HELMS Lifestyle Intervention.

What condition does NCT05207059 study?

NCT05207059 studies Metabolic Disease, Mental Health Wellness 1, Lifestyle Risk Reduction, Maternal Obesity.

Is NCT05207059 still recruiting?

NCT05207059 is currently recruiting now. Last updated 8 October 2024.

Last reviewed 2024-10-08 · How we verify

NCT05207059: HELMS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Healthy Early Life Moments in Singapore

Recruiting now NA Last updated 8 October 2024

What this trial tests

NA trial testing HELMS Lifestyle Intervention in Metabolic Disease in 500 participants. Currently enrolling.

Timeline

18 March 2022

Primary endpoint
1 December 2027

1 December 2028

Quick facts

Lead sponsor	KK Women's and Children's Hospital
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	500
Start date	18 March 2022
Primary completion	1 December 2027
Estimated completion	1 December 2028
Sites	1 location across Singapore

Drugs / interventions tested

HELMS Lifestyle Intervention

Conditions studied

Metabolic Disease — all drugs for Metabolic Disease →
Mental Health Wellness 1 — all drugs for Mental Health Wellness 1 →
Lifestyle Risk Reduction — all drugs for Lifestyle Risk Reduction →
Maternal Obesity — all drugs for Maternal Obesity →

Sponsor

KK Women's and Children's Hospital

Who can join

Adults 21 to 40, female only, with Metabolic Disease or Mental Health Wellness 1. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Pregnancy rate
Time frame: Up to 12 months
Defined by positive urine pregnancy test, clinical diagnosis and/or ultrasound scan showing intrauterine gestation sac, in percentages
Maternal metabolic health
Time frame: Up to 40 months, between preconception, pregnancy and 18 months postpartum
Evaluated by metabolic syndrome criteria
Maternal mental health
Time frame: Up to 26 months, between preconception, pregnancy and 4 months postpartum
Measured by Edinburgh Postnatal Depression Scale, scored between 0 to 30, with a higher score being suggestive of depression

Sponsor's own description

This study aims to assess whether an integrated continuum of care from the preconception period, across maternity until the first 18 months of life, can promote maternal metabolic and mental health, as well as offspring health, among overweight and obese women.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

A Golden Thread approach to transforming Maternal and Child Health in Singapore.
Yap F, Loy SL, Ku CW, Chua MC, et al · · 2022 · cited 13× · PMID 35836151 · DOI 10.1186/s12884-022-04893-8
Effects of an integrated mobile health lifestyle intervention among overweight and obese women planning for pregnancy in Singapore: protocol for the single-arm healthy early life moments in Singapore (HELMS) study.
Chan JKY, Ku CW, Loy SL, Godfrey KM, et al · · 2022 · cited 7× · PMID 36523242 · DOI 10.1136/bmjopen-2022-061556
Maternal stress triggers early-life eczema through fetal mast cell programming.
Serhan N, Abdullah NS, Gheziel N, Loste A, et al · · 2025 · cited 6× · PMID 40866704 · DOI 10.1038/s41586-025-09419-8

Verify or expand the search:

Other recruiting trials for Metabolic Disease

Currently open trials in the same condition.

NCT06575426 — A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes M · Phase 1, PHASE2 · recruiting
NCT06938386 — Pilot Haskap Metabolite Timing Project · NA · active not recruiting
NCT06954298 — Molecular Landscape of Complex Lifestyle Modification · NA · active not recruiting
NCT06717581 — Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older. · recruiting
NCT06529965 — Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM · NA · recruiting

Other KK Women's and Children's Hospital trials

Trials by the same sponsor.

NCT07534670 — Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY · NA · not yet recruiting
NCT07466797 — The eHealth Integrated Maternal Physical Activity Programme in Prenatal Care Trial (E-IMPACT) · NA · recruiting
NCT06457750 — Anthropometric Outcomes of a Mobile Health Intervention for Eating Behaviour and Lifestyle in Infancy · NA · not yet recruiting
NCT06481644 — Asia Pediatric Intensive Care Epidemiology and Outcomes Study · recruiting
NCT06489834 — Group Drumming for Improving the Health of Community-Dwelling Elderly · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05207059 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by KK Women's and Children's Hospital
Last refreshed: 8 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05207059.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing