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NCT05205538
Does Biological Sex Influence the Cardiac Output Response to Sprint Interval Exercise Training in Humans?
NA trial testing Sprint interval exercise training in Exercise in 21 participants. Completed in 28 February 2023.
28 February 2023
Quick facts
| Lead sponsor | McMaster University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 21 |
| Start date | 25 January 2022 |
| Primary completion | 28 February 2023 |
| Estimated completion | 28 February 2023 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Sprint interval exercise training
Conditions studied
- Exercise — all drugs for Exercise →
Sponsor
McMaster University
Who can join
Adults 18 to 35, any sex, with Exercise. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Sprint interval exercise training refers to brief repeated bouts of vigorous effort that are separated by short periods of recovery. Cardiac output refers to the amount of blood that is pumped out of the heart each minute. Research has shown that sprint interval exercise training can increase peak cardiac output - or the highest cardiac output that is achieved during strenuous exercise - but this response may be influenced by biological sex. The primary goal of this study is to determine whether the peak cardiac output response to 12 weeks of sprint interval exercise training differs between males and females. Cardiac output will be estimated using a non-invasive technique that involves breathing in a mixture of standardized gases. This research will help to determine whether biological sex influences the response of the heart to brief vigorous cycle exercise training.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Biological sex does not influence the peak cardiac output response to twelve weeks of sprint interval training.
Bostad W, Williams JS, Van Berkel EK, Richards DL, et al · · 2023 · cited 2× · PMID 38151488 · DOI 10.1038/s41598-023-50016-4
Verify or expand the search:
- PubMed search for NCT05205538
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05205538 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McMaster University
- Last refreshed: 6 April 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05205538.
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