NCT05192161: RADIOMIXSTROKE

Computational Medical Imaging and Prediction of Diffusion/FLAIR Mismatch in Stroke Patients

Status unknown Last updated 13 September 2023

What this trial tests

trial in Stroke in 35 participants. Status unknown.

Timeline

5 April 2023

Primary endpoint
5 May 2023

31 December 2023

Quick facts

Lead sponsor	Fondation Hôpital Saint-Joseph
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	35
Start date	5 April 2023
Primary completion	5 May 2023
Estimated completion	31 December 2023
Sites	2 locations across France

Conditions studied

• Stroke — all drugs for Stroke →

Sponsor

Fondation Hôpital Saint-Joseph — full company profile →

Who can join

18 and older, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stroke is a public health issue and a priority for our institution. MRI plays an essential role in the management of stroke. In this context, the contribution of MRI is diagnostic, etiological and prognostic.

Among the MRI parameters evaluated in the acute phase of the stroke, the evaluation of the mismatch between the DIFFUSION and FLAIR sequences is crucial as it will directly contribute to the therapeutic decision. A FLAIR-diffusion mismatch, i.e., a lesion with a diffusion but not a FLAIR hypersignal, identifies patients whose time of onset of symptoms is probably less than 4.5 hours. It is therefore understandable that the main arterial recanalization techniques performed in the acute phase are primarily reserved for patients with a positive mismatch.

In current practice, mismatch assessment is performed subjectively, by visually comparing the two sequences, which is known to be the cause of a lack of reproducibility and diagnostic performance.

Computational medical imaging techniques ("radiomics") have recently gained momentum and offer the prospect of automated and therefore more reproducible analysis of medical imaging data. In stroke patients, radiomics extracted from FLAIR imaging could thus contribute to describe the "diffusion flair" mismatch in a continuous and objective way.

For the time being, data analysis cannot be performed in real time due to technical constraints. If it is proven that radiomics can reliably analyze the mismatch on the FLAIR sequence alone, the next step will be to make the analysis feasible in clinical routine (i.e. in a time frame adapted to the therapeutic management).

Publications & conference data

No peer-reviewed publications indexed yet for this trial.