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NCT05191732
Effect of PRP Versus BMC in Anterior Cruciate Ligament Reconstruction
NA trial testing Platelet-Rich Plasma; Bone marrow concentrate in Anterior Cruciate Ligament Reconstruction in 30 participants. Completed in 4 July 2020.
4 July 2020
Quick facts
| Lead sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 3 August 2018 |
| Primary completion | 4 July 2020 |
| Estimated completion | 4 July 2020 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Platelet-Rich Plasma; Bone marrow concentrate
Conditions studied
- Anterior Cruciate Ligament Reconstruction — all drugs for Anterior Cruciate Ligament Reconstruction →
Sponsor
Kaohsiung Medical University Chung-Ho Memorial Hospital
Who can join
20 and older, any sex, with Anterior Cruciate Ligament Reconstruction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Anterior cruciate ligament (ACL) is an important stabilizer of knee during daily activity and exercise. The ruptured ACL need to be reconstructed by a new tendon graft which passed the bone tunnel and joint during operation. How to enhance the tendon graft to bone tunnel healing is critical important to prevent recurrent ligament laxity, avoid secondary osteoarthritis, and achieve early return to sports and work. Platelet Rich Plasma (PRP)，harvest from peripheral blood, is rich in multiple growth factors(i.e. VEGF, PDGD, TGFB, IGF, EGF) which help the injured tissue regeneration. Bone marrow stem cell has been demonstrated to enhance the injured tissue repair both in vitro and in vivo study. However, there is no prospective study in comparing the PRP and BMC to enhance interfacial healing between graft and bone tunnel in ACL reconstruction. Investigators hypothesize that the combination of PRP and BMC has synergetic effect in interfacial healing in ACL reconstruction. Aim of this study： To investigate the result of clinical functional scoring, MRI, and biomechanical study between PRP augmentation, PRP+BMC augmentation and traditional ACL reconstruction.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of bone marrow aspiration concentrate and platelet-rich plasma combination in anterior cruciate ligament reconstruction: a randomized, prospective, double-blinded study.
Lin YC, Chen YJ, Fan TY, Chou PH, et al · · 2024 · cited 12× · PMID 38169406 · DOI 10.1186/s13018-023-04512-y
Verify or expand the search:
- PubMed search for NCT05191732
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Anterior Cruciate Ligament Reconstruction
Currently open trials in the same condition.
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- NCT06493851 — The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR) · NA · recruiting
- NCT06341192 — Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction · NA · recruiting
- NCT06464705 — To Investigate the Effect of PEMF for Pateitns After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05191732 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kaohsiung Medical University Chung-Ho Memorial Hospital
- Last refreshed: 13 January 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05191732.
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