Who is sponsoring NCT05188898?

NCT05188898 is sponsored by Federico II University.

What drugs are being tested in NCT05188898?

Interventions in NCT05188898: MINSD and Hyaluronic acid, MINSD.

What condition does NCT05188898 study?

NCT05188898 studies Periodontal Bone Loss, Periodontal Pocket.

Is NCT05188898 still recruiting?

NCT05188898 is currently completed. Last updated 29 April 2024.

Last reviewed 2024-04-29 · How we verify

NCT05188898

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Intraosseous Periodontal Defects With Hyaluronic Acid

Completed NA Last updated 29 April 2024

What this trial tests

NA trial testing MINSD and Hyaluronic acid in Periodontal Bone Loss in 22 participants. Completed in 8 March 2023.

Timeline

12 January 2022

Primary endpoint
8 March 2023

8 March 2023

Quick facts

Lead sponsor	Federico II University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	22
Start date	12 January 2022
Primary completion	8 March 2023
Estimated completion	8 March 2023
Sites	1 location across Italy

Drugs / interventions tested

MINSD and Hyaluronic acid
MINSD

Conditions studied

Periodontal Bone Loss — all drugs for Periodontal Bone Loss →
Periodontal Pocket — all drugs for Periodontal Pocket →

Sponsor

Federico II University

Who can join

Adults 18 to 70, any sex, with Periodontal Bone Loss or Periodontal Pocket. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of a hyaluronic acid-based gel, compared to MINSD alone. A total of 22 patients will be enrolled, selected by inclusion and exclusion criteria and randomly divided in two groups: hyaluronic acid group (HA) and no-hyaluronic acid group (No-HA).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Non-Surgical Treatment of Moderate Periodontal Intrabony Defects With Adjunctive Cross-Linked Hyaluronic Acid: A Single-Blinded Randomized Controlled Clinical Trial.
Iorio-Siciliano V, Blasi A, Mauriello L, Mauriello L, et al · · 2025 · cited 16× · PMID 39402910 · DOI 10.1111/jcpe.14078

Verify or expand the search:

Other recruiting trials for Periodontal Bone Loss

Currently open trials in the same condition.

NCT07146776 — Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts · NA · recruiting
NCT06744348 — Entire Papilla Preservation Technique in the Treatment of Periodontal IntraBony Defects: a 1-year Follow-up Study · active not recruiting
NCT05533528 — Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment · NA · recruiting
NCT03997578 — Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects · NA · recruiting

Other Federico II University trials

Trials by the same sponsor.

NCT07437690 — Fall Prevention in Older Adults in an Italian Cohort · not yet recruiting
NCT07282132 — Evaluation of Real-World Data on Ropeginterferon Alfa-2b in Patients With Polycythemia Vera: Insights From a Multicenter · not yet recruiting
NCT07280286 — Incidence of Intrauterine Adhesions After Myomectomy With Intrauterine Anti-Adhesion Gel · NA · not yet recruiting
NCT07374861 — Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Bempedoic Acid in Italy · recruiting
NCT07314684 — GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05188898 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Federico II University
Last refreshed: 29 April 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05188898.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing