Last reviewed · How we verify
NCT05188183: PLP-EVEREST
Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain With Machine Learning to Predict Treatment Response
NA trial testing M1 anodal home-based tDCS in Phantom Limb Pain in 290 participants. Currently enrolling.
30 June 2027
Quick facts
| Lead sponsor | Spaulding Rehabilitation Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 290 |
| Start date | 1 September 2022 |
| Primary completion | 30 June 2027 |
| Estimated completion | 31 July 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- M1 anodal home-based tDCS
- Somatosensory Training
- Usual Care
Conditions studied
- Phantom Limb Pain — all drugs for Phantom Limb Pain →
Sponsor
Spaulding Rehabilitation Hospital
Who can join
18 and older, any sex, with Phantom Limb Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators have designed a pragmatic trial of home-based transcranial direct current stimulation (tDCS) for phantom limb pain (PLP), the PLP-EVEREST trial (PLP-EffectiVEness pRagmatic Stimulation Trial) to test a portable device that would reach underrepresented populations and would validate this therapy in a more pragmatic setting. Subjects will be randomized to home-based tDCS of the primary motor cortex (M1) with somatosensory training or usual care only (including their current pharmacological treatments, physical therapy, and occupational therapy). The investigators will therefore test the effectiveness of home-based tDCS and somatosensory training in a real-world, home-based setting. The Investigator will compare patients randomized to this combined strategy vs. usual care alone (subjects from this group will be offered combined treatment at the end of the trial). The investigators hypothesize that the combined strategy will be associated with a significantly larger Cohen's d effect size (at least 1) compared to the control group.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05188183
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Phantom Limb Pain
Currently open trials in the same condition.
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- NCT06702904 — Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life · NA · recruiting
- NCT06813937 — Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation · NA · recruiting
- NCT06644807 — Study of Phantom Limb Pain Suppression Using Neuromodulation Methods · NA · recruiting
Other Spaulding Rehabilitation Hospital trials
Trials by the same sponsor.
- NCT04940403 — BurtVision™ for Arm Rehabilitation in Chronic Stroke Survivors: · NA · not yet recruiting
- NCT06193317 — Effects of taVNS on Fibromyalgia Pain · NA · not yet recruiting
- NCT07483320 — Extracorporeal Shockwave Therapy and Platelet-Rich Plasma for Midportion Achilles Tendinopathy · NA · not yet recruiting
- NCT06797154 — A Novel Wrist Wearable Sensor System to Promote Hemiparetic Upper Extremity Use in Subacute Stroke Survivors · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05188183 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Spaulding Rehabilitation Hospital
- Last refreshed: 19 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05188183.
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