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NCT05188105: Alpha-DLB
Alpha tACS in Dementia With Lewy Bodies
NA trial testing Alpha tACS (12 Hz) over the occipital cortex in Dementia With Lewy Bodies in 15 participants. Completed in 20 March 2024.
10 March 2024
Quick facts
| Lead sponsor | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 15 |
| Start date | 18 October 2021 |
| Primary completion | 10 March 2024 |
| Estimated completion | 20 March 2024 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Alpha tACS (12 Hz) over the occipital cortex
Conditions studied
- Dementia With Lewy Bodies — all drugs for Dementia With Lewy Bodies →
- Lewy Body Disease — all drugs for Lewy Body Disease →
Sponsor
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia — full company profile →
Who can join
18 and older, any sex, with Dementia With Lewy Bodies or Lewy Body Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Brain oscillations are ubiquitous in the human brain and have been implicated in cognitive and behavioral states defined in precisely tuned neural networks. In neurodegenerative disorders, neurodegeneration is accompanied by changes in oscillatory activity leading to the emerging concept of neurological and psychiatric disorders as "oscillopathies". Dementia with Lewy bodies (DLB), which is the second most frequent cause of neurodegenerative dementia, is characterized by an important alteration of brain oscillations. The restoration of oscillations by neuronal entrainment in animal models of neurodegenerative disease has shown a significant reduction in the neuropathological load of toxic proteins, with a consequent significant increase in cognitive performance. Transcranial alternating current brain stimulation (tACS), is a neurophysiological method of non-invasive modulation of the excitability of the central nervous system that is having an increasingly numerous spectrum of potential therapeutic applications. Recent studies have demonstrated the effectiveness of this method in modulating the natural frequencies of cerebral oscillation, underlying multiple cognitive processes such as verbal memory, perception and working memory. On the basis of these premises, the treatment with alpha tACS is proposed in patients with DLB. In this randomized, double-blind, sham-controlled, cross-over study, the investigators will evaluate whether a single stimulation with alpha tACS on the occipital lobes can improve symptoms in patients with DLB.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Transcranial alternating current stimulation for neuropsychiatric disorders: a systematic review of treatment parameters and outcomes.
Gholamali Nezhad F, Martin J, Tassone VK, Swiderski A, et al · · 2024 · cited 7× · PMID 39211537 · DOI 10.3389/fpsyt.2024.1419243
Verify or expand the search:
- PubMed search for NCT05188105
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05188105 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
- Last refreshed: 28 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05188105.
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