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NCT05187273
Hemodynamic Optimization Based on a Dynamic Elastance Protocol
NA trial testing Elastance Group in Fluid Management in 46 participants. Completed in 30 December 2023.
30 August 2022
Quick facts
| Lead sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 46 |
| Start date | 25 February 2021 |
| Primary completion | 30 August 2022 |
| Estimated completion | 30 December 2023 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Elastance Group
Conditions studied
- Fluid Management — all drugs for Fluid Management →
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who can join
18 and older, any sex, with Fluid Management. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study investigators explore the effects of a dynamic elastance guided protocol compared to a stroke volume variation fluid therapy on lactate levels during major abdominal surgery. Hence investigators created two groups: in the intervention group fluids are given in fluid-responders (SVV \> 13%) based on high value of dynamic elastance (ie. Eadyn \> 0.9). In the standard group fluids are administered when SVV \> 13%.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A dynamic elastance-based protocol to guide intra-operative fluid management in major abdominal surgery: A randomised clinical trial.
Russo A, Aceto P, Cascarano L, Menga LS, et al · · 2025 · cited 2× · PMID 40070308 · DOI 10.1097/eja.0000000000002162
Verify or expand the search:
- PubMed search for NCT05187273
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Fluid Management
Currently open trials in the same condition.
- NCT07366164 — Hemodynamic Optimization Using an Artificial Intelligenze System · NA · recruiting
- NCT07258875 — Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Po · NA · recruiting
Other Fondazione Policlinico Universitario Agostino Gemelli IRCCS trials
Trials by the same sponsor.
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- NCT07504679 — Adipose Visceral and Epicardial Risk Evaluation · NA · not yet recruiting
- NCT07520643 — MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling · not yet recruiting
- NCT07479238 — Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy · not yet recruiting
- NCT07494227 — Development of the SC-IBD Self-Care Measurement Scale · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05187273 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Last refreshed: 26 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05187273.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing