NCT05186090: AGUEDA

Active Gains in Brain Using Exercise During Aging

Completed NA Last updated 19 March 2024

What this trial tests

NA trial testing 24-week resistance exercise program in Healthy in 90 participants. Completed in 11 December 2022.

Timeline

2 January 2021

Primary endpoint
11 December 2022

11 December 2022

Quick facts

Lead sponsor	Universidad de Granada
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	90
Start date	2 January 2021
Primary completion	11 December 2022
Estimated completion	11 December 2022
Sites	1 location across Spain

Drugs / interventions tested

• 24-week resistance exercise program

Conditions studied

• Healthy — all drugs for Healthy →
• Cognitive Function 1, Social — all drugs for Cognitive Function 1, Social →

Sponsor

Universidad de Granada — full company profile →

Who can join

Adults 65 to 80, any sex, with Healthy or Cognitive Function 1, Social. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

AGUEDA (Active Gains in brain using Exercise During Aging) is a randomized controlled trial designed to examine the effects of a 24-week resistance exercise program on brain health in cognitively normal adults between 65-80 years of age.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial.
   Solis-Urra P, Molina-Hidalgo C, García-Rivero Y, Costa-Rodriguez C, et al · · 2023 · cited 16× · PMID 37284481 · DOI 10.3389/fnhum.2023.1168549
2. Associations between muscular strength and mental health in cognitively normal older adults: a cross-sectional study from the AGUEDA trial.
   Bellón D, Rodriguez-Ayllon M, Solis-Urra P, Fernandez-Gamez B, et al · · 2024 · cited 6× · PMID 38525016 · DOI 10.1016/j.ijchp.2024.100450
3. Fitness, Gray Matter Volume, and Executive Function in Cognitively Normal Older Adults: Cross-Sectional Findings From the AGUEDA Trial.
   Coca-Pulido A, Solis-Urra P, Fernandez-Gamez B, Olvera-Rojas M, et al · · 2024 · cited 5× · PMID 39425451 · DOI 10.1111/sms.14746
4. The false myth of "iodine allergy" also in nuclear medicine.
   Gómez-Perales JL, García-Mendoza A. · · 2021 · cited 2× · PMID 34585268 · DOI 10.1007/s00259-021-05356-6
5. Effects of a 24-week resistance exercise program on Alzheimer's disease brain signatures in cognitively unimpaired older adults: a secondary analysis of the AGUEDA randomized controlled trial.
   Sanchez-Martinez J, Solis-Urra P, Fernandez-Gamez B, Fernández-Ortega J, et al · · 2026 · cited 1× · PMID 41967036 · DOI 10.1093/ageing/afag086
6. Effect of a 24-week resistance exercise intervention on cognitive function in cognitively normal older adults: The AGUEDA randomized controlled trial.
   Fernandez-Gamez B, Solis-Urra P, Coca-Pulido A, Molina-Hidalgo C, et al · · 2026 · cited 1× · PMID 41562376 · DOI 10.1002/alz.71019
7. Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer's disease.
   Chen Y, Zeng X, Olvera-Rojas M, Sewell KR, et al · · 2026 · PMID 41571708 · DOI 10.1038/s41467-026-68372-w
8. Classification accuracies of plasma ptau217 vs. ptau217/Aβ1-42 for brain Aβ pathology in cognitively normal older adults.
   Olvera-Rojas M, Solis-Urra P, Fernandez-Gamez B, Coca-Pulido A, et al · · 2025 · PMID 41196549 · DOI 10.1007/s11357-025-01967-1