NCT05185934 is a NA clinical trial of Food supplement Endocalyx in COVID-19, sponsored by University of Athens.

Who is sponsoring NCT05185934?

NCT05185934 is sponsored by University of Athens.

What drugs are being tested in NCT05185934?

Interventions in NCT05185934: Food supplement Endocalyx, Placebo.

What condition does NCT05185934 study?

NCT05185934 studies COVID-19, Endothelial Dysfunction.

Is NCT05185934 still recruiting?

NCT05185934 is currently status unknown. Last updated 16 May 2023.

Last reviewed 2023-05-16 · How we verify

NCT05185934

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.

Status unknown NA Last updated 16 May 2023

What this trial tests

NA trial testing Food supplement Endocalyx in COVID-19 in 60 participants. Status unknown.

Timeline

1 June 2022

Primary endpoint
1 November 2023

30 January 2024

Quick facts

Lead sponsor	University of Athens
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	60
Start date	1 June 2022
Primary completion	1 November 2023
Estimated completion	30 January 2024
Sites	1 location across Greece

Drugs / interventions tested

Food supplement Endocalyx
Placebo

Conditions studied

COVID-19 — all drugs for COVID-19 →
Endothelial Dysfunction — all drugs for Endothelial Dysfunction →

Sponsor

University of Athens

Who can join

Adults 18 to 75, any sex, with COVID-19 or Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with COVID-19 infection.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Clinical Implications of COVID-19-Related Endothelial Dysfunction.
Aljadah M, Khan N, Beyer AM, Chen Y, et al · · 2024 · cited 20× · PMID 39055276 · DOI 10.1016/j.jacadv.2024.101070
Effects of 4-month treatment with glycocalyx dietary supplement on endothelial glycocalyx and vascular function after COVID-19 infection.
Pavlidis G, Kountouri A, Katogiannis K, Thymis J, et al · · 2025 · cited 1× · PMID 40270280 · DOI 10.1111/eci.70058

Verify or expand the search:

Other trials of Food supplement Endocalyx

Trials testing the same drug.

NCT05184699 — The Effect of Dietary Intervention on Endothelial Glycocalyx in Psoriasis · NA · unknown
NCT03889236 — Dietary Interventions on Glycocalyx Dimensions in South Asian Patients With Diabetic Nephropathy. · NA · completed

Other recruiting trials for COVID-19

Currently open trials in the same condition.

NCT07183709 — Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults · Phase 1 · active not recruiting
NCT07300839 — A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age · Phase 3 · active not recruiting
NCT07221162 — A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes · Phase 1 · recruiting
NCT07215520 — Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults · Phase 2 · recruiting
NCT07222384 — A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That A · Phase 3 · active not recruiting

Other University of Athens trials

Trials by the same sponsor.

NCT07469943 — The Effect of Sodium Glucose Co-trnasportert Type 2 Inhibitors on Arterial Stiffness, Endothelial Glycocalyx Thickness a · recruiting
NCT07254819 — Cotinus Coggygria Mouthwash and Halitosis and Oral Hygiene in Orthodontic Patients · NA · completed
NCT07069010 — Burnout Syndrome in the Intensive Care Unit Before and During a Palliative Care Trial · recruiting
NCT06766097 — Chios Mastic Toothpaste and Halitosis and Oral Hygiene in Orthodontic Patients · NA · not yet recruiting
NCT06885970 — The Effect of Cytisine Treatment for Smoking Cessation on Cardiovascular Function in Adult Smokers · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05185934 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Athens
Last refreshed: 16 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05185934.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing