NCT05183555 (DOTENDO) is a Phase 2 clinical trial of 68Ga-DOTATOC PET/CT in Infective Endocarditis, sponsored by Central Hospital, Nancy, France.

Who is sponsoring NCT05183555?

NCT05183555 is sponsored by Central Hospital, Nancy, France.

What drugs are being tested in NCT05183555?

Interventions in NCT05183555: 68Ga-DOTATOC PET/CT.

What condition does NCT05183555 study?

NCT05183555 studies Infective Endocarditis.

Is NCT05183555 still recruiting?

NCT05183555 is currently completed. Last updated 26 September 2024.

Last reviewed 2024-09-26 · How we verify

NCT05183555: DOTENDO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Early Feasibility Study of Somatostatin Receptors PET Imaging for the Diagnosis of Infective Endocarditis

Completed Phase 2 Last updated 26 September 2024

What this trial tests

Phase 2 trial testing 68Ga-DOTATOC PET/CT in Infective Endocarditis in 14 participants. Completed in 18 June 2024.

Timeline

16 May 2022

Primary endpoint
18 June 2024

18 June 2024

Quick facts

Lead sponsor	Central Hospital, Nancy, France
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	14
Start date	16 May 2022
Primary completion	18 June 2024
Estimated completion	18 June 2024
Sites	1 location across France

Drugs / interventions tested

68Ga-DOTATOC PET/CT — full drug profile →

Conditions studied

Infective Endocarditis — all drugs for Infective Endocarditis →

Sponsor

Central Hospital, Nancy, France

Who can join

18 and older, any sex, with Infective Endocarditis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Study hypothesis: 68Ga-DOTATOC PET/CT could detect cardiac foci of infective endocarditis regardless of the type of valve (native or prosthetic) and also extracardiac localizations related to this pathology (infection responsible, peripheral emboli, ...). This study is a proof of concept with low population

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Novel Diagnostic Methods for Infective Endocarditis.
Burban A, Słupik D, Reda A, Szczerba E, et al · · 2024 · cited 12× · PMID 38279244 · DOI 10.3390/ijms25021245
Radiometal chelators for infection diagnostics.
Akter A, Lyons O, Mehra V, Isenman H, et al · · 2023 · cited 7× · PMID 37388440 · DOI 10.3389/fnume.2022.1058388
Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers.
Shi T, Miller EJ. · · 2023 · cited 6× · PMID 36926261 · DOI 10.1007/s12410-023-09574-4

Verify or expand the search:

Other trials of 68Ga-DOTATOC PET/CT

Trials testing the same drug.

NCT04017104 — Dynamic Whole Body Positron Emission Tomography/Computed Tomography Imaging · unknown
NCT03583528 — DOTATOC PET/CT for Imaging NET Patients · active not recruiting
NCT01619865 — Safety of 68Ga-DOTA-tyr3-Octreotide PET in Diagnosis of Solid Tumors · Phase 1, PHASE2 · completed

Other recruiting trials for Infective Endocarditis

Currently open trials in the same condition.

NCT06269679 — CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis. · NA · recruiting
NCT05965362 — Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR） · recruiting
NCT06418048 — INfectious DIsease REgistry BIObank · recruiting
NCT07156292 — The Epidemiology Change From 2006 to 2022 of Infective Endocarditis in Taiwan · active not recruiting
NCT06309680 — Accuracy of Metagenomic Blood Sampling to Identify Pathogen in Infective Endocarditis Patients · active not recruiting

Other Central Hospital, Nancy, France trials

Trials by the same sponsor.

NCT06452290 — PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder · NA · not yet recruiting
NCT07518498 — Hypnosis During Mechanical Ventilation Weaning · NA · not yet recruiting
NCT07471334 — Prospective Study of Postictal Psychotic Symptoms Occuring After Video-EEG Monitoring in Focal Epilepsies · NA · not yet recruiting
NCT07414667 — Primary Sjögren's Syndrome: Impact of Quantitative Anti-Ro52 Antibody Analysis on Patient Prognosis and Stratification ( · not yet recruiting
NCT07415759 — Imaging of Electrical Properties by MRI: Investigation of Age-Related Changes · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05183555 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Central Hospital, Nancy, France
Last refreshed: 26 September 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05183555.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing