NCT05182450 is a NA clinical trial of Mango leaf extract capsule in Attention, sponsored by PepsiCo Global R&D.

Who is sponsoring NCT05182450?

NCT05182450 is sponsored by PepsiCo Global R&D.

What drugs are being tested in NCT05182450?

Interventions in NCT05182450: Mango leaf extract capsule, Placebo capsule.

What condition does NCT05182450 study?

NCT05182450 studies Attention, Cognition, Mood.

Is NCT05182450 still recruiting?

NCT05182450 is currently completed. Last updated 14 November 2022.

Last reviewed 2022-11-14 · How we verify

NCT05182450

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Acute Effects of Mango Leaf Extract on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

Completed NA Last updated 14 November 2022

What this trial tests

NA trial testing Mango leaf extract capsule in Attention in 114 participants. Completed in 20 June 2022.

Timeline

4 January 2022

Primary endpoint
20 June 2022

20 June 2022

Quick facts

Lead sponsor	PepsiCo Global R&D
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	basic science
Enrollment	114
Start date	4 January 2022
Primary completion	20 June 2022
Estimated completion	20 June 2022
Sites	1 location across United Kingdom

Drugs / interventions tested

Mango leaf extract capsule
Placebo capsule

Conditions studied

Attention — all drugs for Attention →
Cognition — all drugs for Cognition →
Mood — all drugs for Mood →

Sponsor

PepsiCo Global R&D — full company profile →

Who can join

Adults 18 to 45, any sex, with Attention or Cognition. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary aim of this randomised, double-blind, placebo-controlled, cross-over study is to assess the short-term cognitive effects of a single dose (300 mg) of Mango Leaf Extract compared to a placebo on cognitive function, including during cognitively demanding task performance. The trial will utilise the COMPASS cognitive assessment system and cognitive demand battery (CDB), and Profile of Mood States (POMS), visual analogue mood scales (VAMS), and Stress Visual Analogue Scales (S-VAS) with assessments taking place at baseline, 30 minutes, 180 minutes and 300 minutes post treatment, on two separate testing days separated by 7 days (minimum).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Acute effects of mango leaf extract on cognitive function in healthy adults: a randomised, double-blind, placebo-controlled crossover study.
Dodd FL, Kennedy DO, Johnson J, Haworth E, et al · · 2024 · cited 2× · PMID 38665302 · DOI 10.3389/fnut.2024.1298807

Verify or expand the search:

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Currently open trials in the same condition.

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Other PepsiCo Global R&D trials

Trials by the same sponsor.

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NCT07400614 — Evaluating the Impact of Energy Drink Formulas on Alertness for an Extended Period · NA · recruiting
NCT07427654 — Determination of the Glycemic Index of Products Varying in Levels of Refined and Whole Grain Corn · NA · completed
NCT07298863 — The Effect of Hydration Status on Substrate Oxidation at Rest and During Light and Moderate Exercise · NA · recruiting
NCT07217834 — Effects of a Glycerol-Electrolyte Beverage on Fluid Balance in Healthy Euhydrated Men and Women · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05182450 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by PepsiCo Global R&D
Last refreshed: 14 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05182450.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing