NCT05181449 (TPT) is a NA clinical trial of Twin Precision Treatment in Type 2 Diabetes, sponsored by The Cleveland Clinic.

Who is sponsoring NCT05181449?

NCT05181449 is sponsored by The Cleveland Clinic.

What drugs are being tested in NCT05181449?

Interventions in NCT05181449: Twin Precision Treatment.

What condition does NCT05181449 study?

NCT05181449 studies Type 2 Diabetes.

Is NCT05181449 still recruiting?

NCT05181449 is currently active, enrolled. Last updated 18 September 2025.

Last reviewed 2025-09-18 · How we verify

NCT05181449: TPT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Randomized Controlled Trial of Digital Twin Precision Treatment: A Novel Whole Body Digital Twin Enabled Precision Treatment for Type 2 Diabetes

Active, enrolled NA Last updated 18 September 2025

What this trial tests

NA trial testing Twin Precision Treatment in Type 2 Diabetes in 150 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 February 2022

Primary endpoint
15 May 2025

29 November 2026

Quick facts

Lead sponsor	The Cleveland Clinic
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	150
Start date	1 February 2022
Primary completion	15 May 2025
Estimated completion	29 November 2026
Sites	1 location across United States

Drugs / interventions tested

Twin Precision Treatment

Conditions studied

Type 2 Diabetes — all drugs for Type 2 Diabetes →

Sponsor

The Cleveland Clinic

Who can join

Adults 18 to 75, any sex, with Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a randomized study comparing outcomes of patients diagnosed with Type 2 Diabetes (T2D) who are enrolled into the Twin Health Precision Treatment (TPT) system versus usual care. The study will last for a year with a 1 year optional extension for the TPT arm patients to continue for another year, and for the usual care (UC) patients to cross over to the TPT treatment for a year. 150 patients will be enrolled with 100 being randomized to the TPT arm and 50 being enrolled to the UC arm

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Digital twins for health: a scoping review.
Katsoulakis E, Wang Q, Wu H, Shahriyari L, et al · · 2024 · cited 225× · PMID 38519626 · DOI 10.1038/s41746-024-01073-0
Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control.
Shamanna P, Joshi S, Thajudeen M, Shah L, et al · · 2024 · cited 15× · PMID 39634180 · DOI 10.3389/fendo.2024.1485464
The Potential Use of Digital Twin Technology for Advancing CAR-T Cell Therapy.
Aghamiri SS, Amin R. · · 2025 · cited 4× · PMID 40699720 · DOI 10.3390/cimb47050321
Advancing rare disease therapeutics through digital twins: Opportunities in drug development and precision dosing.
Dette CMU, Alberg V, Rüdesheim S, Selzer D, et al · · 2025 · cited 1× · PMID 41404110 · DOI 10.1016/j.csbj.2025.11.047

Verify or expand the search:

Other recruiting trials for Type 2 Diabetes

Currently open trials in the same condition.

NCT07053319 — SGLT2i, Pioglitazone, and Ketone Production in T2D · Phase 1 · recruiting
NCT07272837 — Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass · recruiting
NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT07254689 — The Food for Health Study · NA · recruiting
NCT07558863 — Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes · Phase 4 · recruiting

Other The Cleveland Clinic trials

Trials by the same sponsor.

NCT07218198 — Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension · NA · not yet recruiting
NCT07442747 — Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS · NA · not yet recruiting
NCT07471464 — Centered Surgery - Preoperative Counseling and Patient Satisfaction · recruiting
NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
NCT07363343 — Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05181449 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
Last refreshed: 18 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05181449.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing