NCT05179564 (IOHEXOL) is a NA clinical trial of iohexol administration in Iohexol, sponsored by University Hospital, Ghent.

Who is sponsoring NCT05179564?

NCT05179564 is sponsored by University Hospital, Ghent.

What drugs are being tested in NCT05179564?

Interventions in NCT05179564: iohexol administration, iohexol blood sampling.

What condition does NCT05179564 study?

NCT05179564 studies Iohexol, Pharmacokinetics, Renal Function, Critically Ill Children, Acute Kidney Injury, Augmented Renal Clearance.

Is NCT05179564 still recruiting?

NCT05179564 is currently completed. Last updated 5 January 2022.

Last reviewed 2022-01-05 · How we verify

NCT05179564: IOHEXOL

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Renal Function Assessment in Critically Ill Children

Completed NA Last updated 5 January 2022

What this trial tests

NA trial testing iohexol administration in Iohexol in 100 participants. Completed in 7 February 2021.

Timeline

20 May 2018

Primary endpoint
7 February 2021

7 February 2021

Quick facts

Lead sponsor	University Hospital, Ghent
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	100
Start date	20 May 2018
Primary completion	7 February 2021
Estimated completion	7 February 2021
Sites	1 location across Belgium

Drugs / interventions tested

iohexol administration
iohexol blood sampling

Conditions studied

Iohexol — all drugs for Iohexol →
Pharmacokinetics — all drugs for Pharmacokinetics →
Renal Function — all drugs for Renal Function →
Critically Ill Children — all drugs for Critically Ill Children →

Sponsor

University Hospital, Ghent

Who can join

Under 15, any sex, with Iohexol or Pharmacokinetics. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Identification of renal dysfunction in critically ill children is often delayed due to lack of accurate methods for evaluation of glomerular filtration rate (GFR). The investigators compared GFR measurement by the gold standard technique iohexol plasma clearance with estimated GFR (eGFR) based on selected established formulas incorporating the renal biomarkers creatinine, cystatin C and betatrace protein.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children.
Dhont E, Windels C, Snauwaert E, Van Der Heggen T, et al · · 2022 · cited 11× · PMID 36053381 · DOI 10.1007/s00431-022-04570-0
Predictors of augmented renal clearance based on iohexol plasma clearance in critically ill children.
Dhont E, Van Der Heggen T, Snauwaert E, Willems J, et al · · 2024 · cited 6× · PMID 37994980 · DOI 10.1007/s00467-023-06221-4
Accurate Estimation of Glomerular Filtration Rate in Critically Ill Infants and Children Using a Iohexol Population Pharmacokinetic Modeling Approach.
Dhont E, Destere A, Gerard A, Bouveyron C, et al · · 2026 · cited 1× · PMID 41591642 · DOI 10.1007/s40262-025-01617-x

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05179564 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Ghent
Last refreshed: 5 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05179564.

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