NCT05178706

Effectiveness of Upper Extremity Rehabilitation in pwFSHD (Patient With Facioscapulohumeral Dystrophia)

Completed Last updated 12 October 2023

What this trial tests

trial testing upper extremity rehabilitation program in Facioscapulohumeral Muscular Dystrophy in 36 participants. Completed in 10 June 2022.

Timeline

22 February 2022

Primary endpoint
23 April 2022

10 June 2022

Quick facts

Lead sponsor	Istanbul University - Cerrahpasa
Status	Completed
Study type	OBSERVATIONAL
Enrollment	36
Start date	22 February 2022
Primary completion	23 April 2022
Estimated completion	10 June 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• upper extremity rehabilitation program
• Results of assessment

Conditions studied

• Facioscapulohumeral Muscular Dystrophy — all drugs for Facioscapulohumeral Muscular Dystrophy →

Sponsor

Istanbul University - Cerrahpasa

Who can join

Adults 18 to 50, any sex, with Facioscapulohumeral Muscular Dystrophy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Facioscapulohumeral Muscular Dystrophy (FSHD) is one of the most common forms of muscular dystrophy, characterized by pronounced skeletal weakness and with a broad spectrum of diseases. It is a hereditary disease seen in 3-5/100,000 of society, usually starting with weakness in the facial and shoulder muscles and progressing to the trunk, pelvis and leg muscles, giving symptoms in the twenties. In FSHD, which shows slow progression and can lead to loss of ambulation ability in about 20% of patients, patients may have difficulty performing activities above shoulder level with the influence of the periscapular area.

The goal of FSHD treatment is to improve muscle strength and/or function. Treatments include medical, conservative and surgical methods. The aim of surgical methods is to improve shoulder function and prevent pain caused by the movements of the scapula. The publications on physiotherapy interventions and aerobic exercise are available as conservative treatment. In patients diagnosed with FSHD, conservative treatment is frequently used to improve muscle strength, regulate function and improve the quality of life of patients.

Patients with FSHD use their affected upper extremities asymmetrically, which leads to the development of restrictive compensation mechanisms in the development of symmetrical postural control. Postural control deficits may occur due to limited use of the affected scapula in individuals with FSHD. Accordingly, in cases with FSHD, there is the use of atypical movements for balance and mobility. It is not yet known whether people with FSHD really have poorer dynamic stability during self-initiated whole-body movements such as walking, and at what stage of the disease these difficulties arise.

Accordingly, the aim of this study was to examine the effects of rehabilitation approaches applied to the upper limb on upper limb function, balance and walking in patients with FSHD.

H1: Within the group of patients with FSHD patients underwent surgery arthrodesis surgery scapulothoracic applied to pre-treatment with the parameters of the rehabilitation program for the evaluation of upper limb functionality after applying the upper extremities, postural control and gait parameters examined, there is statistical difference between the groups.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.